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Series GSE87841 Query DataSets for GSE87841
Status Public on Aug 25, 2018
Title Gene expression in SAS cell lines upon SNAI1 silencing
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Collective cell migration is one of the principal modes for cancer cell movements. However, the triggering event for collective migration and its clinical significance is unclear. Here, we found that Snail, a major inducer of epithelial-mesenchymal transition (EMT), is critical for orchestrating collective migration in squamous cell carcinoma (SCC). To invstigate how Snail contribute to collective migration and invasion, we used microarrays to identify the global gene alterations regulated by Snail in SCC cells.
Overall design Control vs. Snail-depleted SAS cells were cultured on thick collagen (2.5D cultured system) for simulating virtual physiological environment. After 24 h, total RNA was harvested for microarray analysis.
Contributor(s) Yang M, Li C
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Submission date Oct 11, 2016
Last update date Aug 26, 2018
Contact name Ching-Fei Li
Organization name YM University
Street address No.155, Sec.2, Linong Street
City Taipei
ZIP/Postal code 11221
Country Taiwan
Platforms (1)
GPL17077 Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
Samples (2)
GSM2341752 SAS-shSNAI1_24hr_2.5D
GSM2341753 SAS-pLKO_24hr_2.5D
BioProject PRJNA347840

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE87841_RAW.tar 25.0 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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