|
| Status |
Public on Apr 01, 2018 |
| Title |
Epigenetic Reprogramming of mutant RAS-driven Rhabdomyosarcoma via MEK Inhibition |
| Organisms |
Homo sapiens; Mus musculus |
| Experiment type |
Expression profiling by array
Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
This SuperSeries is composed of the SubSeries listed below.
|
| |
|
| Overall design |
Refer to individual Series
|
| |
|
| Citation(s) |
29973406 |
| |
| Submission date |
Aug 03, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
Ashish Lal |
| E-mail(s) |
ashish.lal@nih.gov
|
| Phone |
2407607396
|
| Organization name |
NCI, NIH
|
| Department |
Genetics Branch
|
| Lab |
Javed Khan
|
| Street address |
37 Convent Dr.
|
| City |
Bethesda |
| State/province |
MD |
| ZIP/Postal code |
20892 |
| Country |
USA |
| |
|
| Platforms (3) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
|
| Samples (60)
|
| GSM2259121 |
NRAS_Q61K |
| GSM2259122 |
CTR DNase DMSO 48h rep 1 |
| GSM2259123 |
CTR DNase DMSO 48h rep 2 |
| GSM2259124 |
CTR DNase DMSO 48h rep 3 |
| GSM2259125 |
CTR DNase Tram 48h rep 1 |
| GSM2259126 |
CTR DNase Tram 48h rep 2 |
| GSM2259127 |
CTR DNase Tram 48h rep 3 |
| GSM2259128 |
CTR DNase 48h rep 1 |
| GSM2259129 |
CTR DNase 48h rep 2 |
| GSM2259130 |
CTR DNase 48h rep 3 |
| GSM2259131 |
CTR D48 ERK |
| GSM2259132 |
CTR T48 ERK |
| GSM2259133 |
CTR D48 EZH2 |
| GSM2259134 |
CTR T48 EZH2 |
| GSM2259135 |
CTR D48 H3K27ac |
| GSM2259136 |
CTR T48 H3K27ac rep 1 |
| GSM2259137 |
CTR T48 H3K27ac rep 2 |
| GSM2259138 |
CTR D48 H3K27me3 rep 1 |
| GSM2259139 |
CTR T48 H3K27me3 rep 1 |
| GSM2259140 |
CTR D48 H3K27me3 rep 2 |
| GSM2259141 |
CTR T48 H3K27me3 rep 2 |
| GSM2259142 |
CTR D48 H3K36me3 |
| GSM2259143 |
CTR D48 H3K4me1 |
| GSM2259144 |
CTR D48 H3K4me2 |
| GSM2259145 |
CTR D48 H3K4me3 |
| GSM2259146 |
CTR T48 input |
| GSM2259147 |
CTR D48 input rep 1 |
| GSM2259148 |
CTR D48 input rep 2 |
| GSM2259152 |
CTR T48 MYOD1 |
| GSM2259153 |
CTR D48 MYOD1 rep 1 |
| GSM2259154 |
CTR D48 MYOD1 rep 2 |
| GSM2259155 |
CTR D48 MYOG |
| GSM2259156 |
CTR T48 MYOG |
| GSM2259157 |
CTR D48 PolII |
| GSM2259158 |
CTR T48 PolII |
| GSM2259159 |
CTR untreated |
| GSM2259160 |
CTR DMSO |
| GSM2259161 |
CTR 10 nM Tram, 6 hrs |
| GSM2259162 |
CTR 10 nM Tram, 24 hrs |
| GSM2259163 |
CTR 10 nM Tram, 48 hrs |
| GSM2259164 |
CTR 100 nM Tram, 6 hrs |
| GSM2259165 |
CTR 100 nM Tram, 24 hrs |
| GSM2259166 |
CTR 100 nM Tram, 48 hrs |
| GSM2259167 |
RD si control |
| GSM2259168 |
RD si MEK1 |
| GSM2259169 |
RD untreated |
| GSM2259170 |
RD DMSO |
| GSM2259171 |
RD 10 nM Tram, 6 hrs |
| GSM2259172 |
RD 10 nM Tram, 24 hrs |
| GSM2259173 |
RD 10 nM Tram, 48 hrs |
| GSM2259174 |
RD 100 nM Tram, 6 hrs |
| GSM2259175 |
RD 100 nM Tram, 24 hrs |
| GSM2259176 |
RD 100 nM Tram, 48 hrs |
| GSM3103104 |
CTR D48 MYCy69 |
| GSM3103105 |
CTR T48 MYCy69 |
| GSM3103106 |
CTR D48 Pol2S2pAMR |
| GSM3103107 |
CTR T48 Pol2S2pAMR |
|
| This SuperSeries is composed of the following SubSeries: |
| GSE85168 |
Oncogenic RAS blocks myogenic differentiation |
| GSE85169 |
MEK inhibition profoundly reprograms myogenic super enhancers in mutant-RAS driven Rhabdomyosarcoma |
| GSE85170 |
MEK inhibition rewires enhancer landscapes in RAS-driven Rhabdomyosarcoma to unlock a myogenic differentation block |
|
| Relations |
| BioProject |
PRJNA336377 |
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