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Series GSE83276 Query DataSets for GSE83276
Status Public on Dec 16, 2016
Title Targeting metastasis stem cells through the fatty acid receptor CD36
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Metastasis is the leading cause of cancer-related deaths. For most human cancers, the identity of the cells that initiate and promote metastasis is still unknown, hampering our ability to develop therapies to prevent or inhibit the spread of tumour cells to distant sites. Using an orthotopic model of human oral squamous cell carcinoma (OSCC), we have now identified a subpopulation of CD44bright cells within the primary lesion with the highest potential to develop lymph node and lung metastasis. This population is slow-cycling, expresses high levels of the receptor CD36 at the cell membrane and relies on fatty acid metabolism to thrive in lymph nodes and bronchoalveolar environments. Importantly, inhibition of CD36 by either shRNA or neutralizing monoclonal antibodies severely impairs metastatic spread of primary OSCC patient samples and established cell lines. Further underscoring its importance, CD36 overexpression in poorly disseminating tumours confers an aggressive metastatic behaviour. Analyses of public gene expression data indicate that the presence of the signature-defining CD36+ cells also strongly correlates with a poor prognosis in patients with lung SCC, ovarian cancer, bladder cancer, or luminal breast cancer. By identifying metastasis-promoting cells and then targeting them with CD36 inhibition, novel anti-metastatic therapies could be developed for patients with these types of tumours.
Overall design 3 (LN2 #1#2#3)+4(PT1 #2#3#4#5) biological replicates were included. From each biological replicate, 2 independent populations were sorted (CD36+ and CD36-).
Contributor(s) Aznar-Benitah S, Stephan-Otto Attolini C
Citation(s) 27974793
Submission date Jun 13, 2016
Last update date Jan 09, 2018
Contact name Antoni Berenguer-LLergo
Organization name Parc TaulĂ­ Research and Innovation Institute (I3PT)
Department A8G2 Group - Rheumatology Service
Street address Parc del TaulĂ­, 1
City Sabadell
State/province Barcelona
ZIP/Postal code 08208
Country Spain
Platforms (1)
GPL17077 Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
Samples (13)
GSM2198053 LN2 CD36+#1
GSM2198054 LN2 CD36-#1
GSM2198055 LN2 CD36+#2
This SubSeries is part of SuperSeries:
GSE72939 Targeting metastasis stem cells through the fatty acid receptor CD36
BioProject PRJNA325477

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Supplementary file Size Download File type/resource
GSE83276_RAW.tar 162.8 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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