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Series GSE80338 Query DataSets for GSE80338
Status Public on Jun 19, 2016
Title Human glioblastoma-associated microglia/monocytes express a distinct RNA profile compared to human control and murine samples
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We used RNA sequencing to compare the expression profile of 8 CD11b+ human glioblastoma-associated microglia/monocytes (hGAMs) samples to 8 human non-tumor CD11b+ microglia samples. Hierarchical clustering and principal component analysis showed a clear separation of the two sample groups and we identified 334 significantly regulated genes in hGAMs. In comparison to human control microglia hGAMs up-regulate genes associated with mitotic cell cycle, cell migration, cell adhesion, and extracellular matrix organization.
Overall design Comparison of the mRNA expression profile of 8 CD11b+ human glioblastoma-associated microglia/monocytes samples and 8 human non-tumor CD11b+ microglia samples (isolated form postmortem and epilepsy tissues).
Contributor(s) Szulzewsky F, Arora S
Citation(s) 27312099
BioProject PRJNA315145
Submission date Apr 15, 2016
Last update date May 15, 2019
Contact name Sonali Arora
Organization name FHCRC
Street address 1100 Fairview Ave N,
City Seattle
State/province WA
ZIP/Postal code 98109
Country USA
Platforms (1)
GPL18460 Illumina HiSeq 1500 (Homo sapiens)
Samples (16)
GSM2124785 GBM Sample 1 (sample 1)
GSM2124786 GBM Sample 2 (sample 2)
GSM2124787 GBM Sample 3 (sample 3)
SRA SRP071750

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE80338_RAW.tar 5.9 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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