GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE7902 Query DataSets for GSE7902
Status Public on Jun 27, 2007
Title Novel cell lines from mouse epiblast share defining features with human embryonic stem cells
Organisms Homo sapiens; Mus musculus
Experiment type Expression profiling by array
Summary The application of human embryonic stem (ES) cells has an inherent reliance on understanding the starting cell population. Human ES cells differ from mouse ES cells and the specific embryonic origin of both cell types is unclear. Previous work suggested that mouse ES cells could only be obtained from the embryo prior to implantation in the uterus. Here we show that cell lines can be derived from the epiblast, a tissue of the post-implantation embryo that generates the embryo proper. These cells, which we refer to as EpiSCs (post-implantation epiblast-derived stem cells), express transcription factors known to regulate pluripotency, maintain their genomic integrity, and robustly differentiate into the major somatic cell types as well as primordial germ cells (PGCs). The post-ES cell lines are distinct from mouse ES cells in their epigenetic state and the signals controlling their differentiation. Furthermore, post-ES and human ES cells share patterns of gene expression and signalling responses that normally function in the epiblast. These results show that epiblast cells can be maintained as stable cell lines and interrogated to understand how pluripotent cells generate distinct fates during early development.

This SuperSeries is composed of the SubSeries listed below.
Overall design Refer to individual Series.
Citation(s) 17597760
Submission date May 25, 2007
Last update date May 10, 2018
Contact name Paul Tesar
Organization name Case Western Reserve University
Department Genetics & Genome Sciences
Street address 10900 Euclid Ave.
City Cleveland
State/province Ohio
ZIP/Postal code 44106
Country USA
Platforms (3)
GPL2507 Sentrix Human-6 Expression BeadChip
GPL4133 Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version)
GPL4134 Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Feature Number version)
Samples (12)
GSM190779 hES_H9
GSM190780 hES_BG03
GSM190781 hES_ES01
This SuperSeries is composed of the following SubSeries:
GSE7865 Gene expression in undifferentiated human ES cells - Illumina
GSE7866 Gene expression comparison of mouse ES cells and EpiSCs
GSE7900 Gene expression in undifferentiated human ES cells - Agilent
BioProject PRJNA99953

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE7902_RAW.tar 89.4 Mb (http)(custom) TAR (of TXT)
Raw data provided as supplementary file
Processed data included within Sample table

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap