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Series GSE78867 Query DataSets for GSE78867
Status Public on Mar 15, 2016
Title The anti-tumor core molecular targets of TSA in cholangiocarcinoma
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Firstly our study demonstrated that TSA can inhibits cell proliferation, induces cell apoptosis and cell cycle arrest in CCA cell lines in vitro. To identify the target transcripts of TSA to suppress CCA tumorigenesis, mRNA expression profiles were determined by microarray analysis. We chose TFK-1 cells treated by TSA in indicated concentration (IC50) 48 hours for the microarray. Then we found out TACC3 was downregulated, and demonstrated that TACC3 was high expression and may played a role as an target of TSA in inhibiting CCA cells proliferation and migration via in vitro and vivo experiments.
Overall design We chose TFK-1 cells treated by TSA in indicated concentration (IC50) 48 hours as the experiment sample and without TSA as the control sample to do this microarray analysis for three times. Then regulated genes would be tested to investigate the potential roles in CCA tumorigenesis,
Contributor(s) He J, Yao W
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Submission date Mar 03, 2016
Last update date Apr 23, 2018
Contact name wei -- yao
Organization name Tongji hospital
Street address NO.1095 of jiefang stree
City wuhan
ZIP/Postal code 430030
Country China
Platforms (1)
GPL17077 Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
Samples (6)
GSM2079829 TFK-1 cell-TSA-rep1
GSM2079830 TFK-1 cell-TSA-rep2
GSM2079831 TFK-1 cell-TSA-rep3
BioProject PRJNA314227

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE78867_RAW.tar 41.7 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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