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| Status |
Public on Jan 09, 2022 |
| Title |
Identification of new microRNA-22-5p and -199a-5p/MMP1 functional interactions in stress-induced senescent human dermal fibroblasts [mRNA] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
To study and correlate modulations of miRNome with modifications of transcriptome in human stress-induced senescent fibroblasts, Agilent microarrays data were compared by bioinformatics analysis with a focus on ECM components. We identified two unreported direct interactions since we highlighted a reduction in the expression of both miR-22-5p and -199a-5p in senescent fibroblasts, correlated to an increase of MMP1 expression.
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| Overall design |
Gene expression in stress-induced senescent (SIS) fibroblasts was measured after 4 days of irradiation. Four independent experiments were performed for each condition (normal human fibroblasts [NHF] and SIS-fibroblasts) using different donors for each experiment.
Contributor: R&D department, SILAB, France
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| |
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| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Jan 21, 2016 |
| Last update date |
Jan 10, 2022 |
| Contact name |
Pauline Rouaud-Tinguely |
| E-mail(s) |
p.tinguely@silab.fr
|
| Organization name |
SILAB
|
| Department |
R&D
|
| Street address |
ZI de la Nau
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| City |
Saint-Viance |
| ZIP/Postal code |
19240 |
| Country |
France |
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| Platforms (1) |
| GPL17077 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version) |
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| Samples (8)
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| GSM2043477 |
Human dermal fibroblasts_2D_normal medium_rep1 (mRNA) |
| GSM2043478 |
Human dermal fibroblasts_2D_normal medium_rep2 (mRNA) |
| GSM2043479 |
Human dermal fibroblasts_2D_normal medium_rep3 (mRNA) |
| GSM2043480 |
Human dermal fibroblasts_2D_normal medium_rep4 (mRNA) |
| GSM2043481 |
Human dermal fibroblasts_2D_irradiated_rep1 (mRNA) |
| GSM2043482 |
Human dermal fibroblasts_2D_irradiated_rep2 (mRNA) |
| GSM2043483 |
Human dermal fibroblasts_2D_irradiated_rep3 (mRNA) |
| GSM2043484 |
Human dermal fibroblasts_2D_irradiated_rep4 (mRNA) |
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| This SubSeries is part of SuperSeries: |
| GSE77407 |
Identification of new microRNA-22-5p and -199a-5p/MMP1 functional interactions in stress-induced senescent human dermal fibroblasts |
|
| Relations |
| BioProject |
PRJNA309395 |
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