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| Status |
Public on Nov 06, 2018 |
| Title |
Differential gene expression of Andrographis paniculata and andrographolide enriched andrographis paniculata extract in liver cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Andrographis paniculata Nees and its major compound andrographolide is known to exhibit a pleothera of activities. Active component enriched extracts are known to provide various beneficial effects, and therefore it was interesting to investigate whether increased amount of major compound alters gene expression. To acheive this, HePG2 cells treated with Andrographis paniculata extract (AP) and andrographolide enriched –extract (AP20) were subjected to microarray analysis to check their effect on global gene expression.
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| Overall design |
HepG2 Cells were treated with AP and AP20 extract (0.01%) in triplicates for 24 hrs. A “biological average” was obtained from these three replicates and total RNA was isolated from the pooled cell extract and was used microaray study.
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| Contributor(s) |
Khole S, Mittal S, Jagadish N, Chettiar S, Singh V, Desai A, Kulkarni A, Gadgil V, Sinkar V, Ghaskadbi S |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Nov 06, 2015 |
| Last update date |
Nov 07, 2018 |
| Contact name |
Saroj Ghaskadbi |
| E-mail(s) |
ssg@unipune.ac.in, sghaskadbi@gmail.com
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| Organization name |
SPPU
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| Department |
Department of Zoology
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| Street address |
Ganeshkhind
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| City |
Pune |
| State/province |
Maharashatra |
| ZIP/Postal code |
411007 |
| Country |
India |
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| Platforms (1) |
| GPL17077 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version) |
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| Samples (3) |
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| Relations |
| BioProject |
PRJNA301450 |
