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Series GSE74769 Query DataSets for GSE74769
Status Public on Nov 06, 2018
Title Differential gene expression of Andrographis paniculata and andrographolide enriched andrographis paniculata extract in liver cells
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Andrographis paniculata Nees and its major compound andrographolide is known to exhibit a pleothera of activities. Active component enriched extracts are known to provide various beneficial effects, and therefore it was interesting to investigate whether increased amount of major compound alters gene expression. To acheive this, HePG2 cells treated with Andrographis paniculata extract (AP) and andrographolide enriched –extract (AP20) were subjected to microarray analysis to check their effect on global gene expression.
Overall design HepG2 Cells were treated with AP and AP20 extract (0.01%) in triplicates for 24 hrs. A “biological average” was obtained from these three replicates and total RNA was isolated from the pooled cell extract and was used microaray study.
Contributor(s) Khole S, Mittal S, Jagadish N, Chettiar S, Singh V, Desai A, Kulkarni A, Gadgil V, Sinkar V, Ghaskadbi S
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Submission date Nov 06, 2015
Last update date Nov 07, 2018
Contact name Saroj Ghaskadbi
Organization name SPPU
Department Department of Zoology
Street address Ganeshkhind
City Pune
State/province Maharashatra
ZIP/Postal code 411007
Country India
Platforms (1)
GPL17077 Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
Samples (3)
GSM1932742 HepG2 cells_untreated_24hrs
GSM1932743 HepG2 cells_AP treated_24hrs
GSM1932744 HepG2 cells_AP20 treated_24hrs
BioProject PRJNA301450

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Supplementary file Size Download File type/resource
GSE74769_RAW.tar 36.8 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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