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Series GSE74484 Query DataSets for GSE74484
Status Public on Feb 01, 2016
Title Gene expression profiling in metabolically heterogeneous human lung tumors
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary To investigate the impact of genetic and environmental factors that influence cancer cell metabolism in vivo, we conducted intra-operative 13C-glucose infusions in NSCLC patients. We determined that regional glucose metabolism was correlated with tumor perfusion as assessed by pre-surgical dynamic gadolinium enhancement.  Tumors or tumor regions showing high or low perfusion were collected and subjected to RNA-seq analysis.
Overall design RNA-seq analysis was performed to evaluate gene transcriptional levels in human non-small cell lung cancer (NSCLC) tissues showing high or low perfusion as measured by dynamic contrast-enhanced (DCE) MRI.
Contributor(s) Faubert B, Hensley C, Ni M, DeBerardinis R
Citation(s) 26853473
Submission date Oct 29, 2015
Last update date May 15, 2019
Contact name Min Ni
Organization name UT Southwestern Medical Center
Department Children's Research Institute
Lab DeBerardinis Lab
Street address 6000 Harry Hines Blvd
City Dallas
State/province TX
ZIP/Postal code 75390
Country USA
Platforms (1)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (10)
GSM1921464 High_Pt4_tumor
GSM1921465 High_Pt5_tumor
GSM1921466 High_Pt8_inferior
BioProject PRJNA300542
SRA SRP065491

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE74484_Run24_rnaseq_genes_count.txt.gz 2.0 Mb (ftp)(http) TXT
GSE74484_Run24_rnaseq_genes_fpkm.txt.gz 3.1 Mb (ftp)(http) TXT
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Processed data are available on Series record
Raw data are available in SRA

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