NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE65851 Query DataSets for GSE65851
Status Public on Feb 12, 2015
Title Beta Amyloid toxicity in a Caenorhabditis elegans model of Alzheimer's disease
Organism Caenorhabditis elegans
Experiment type Expression profiling by array
Summary Transgenic animals were engineered to express human amyloid peptide controlled by a muscle-specific, heat-inducible promoter. At low temperatures (16°C) Abeta expression is minimal, while at higher temperatures (20-25°C) Abeta accummulates in large quantities and causes paralysis.
GFP- and GFP::degron (a toxic aggregating GFP mutant)-expressing animals were used as controls.
 
Overall design Animals were grown at 16°C till early 3rd larval stage and then upshifted to 25°C. Animals were harvested at the time of upshift (T0), and every 4 hours later until 20 hours postupshift (T4-T20).
 
Contributor(s) Link CD, Hassan WM, Yerg JE
Citation(s) 25457027
Submission date Feb 11, 2015
Last update date Jul 06, 2016
Contact name Wail Mostafa Hassan
E-mail(s) hassanw@uwm.edu
Phone (414) 229-3124
Organization name University of Wisconsin
Department Biomedical Sciences
Lab Hassan
Street address 2400 E. Hartford Ave.
City Milwaukee
ZIP/Postal code 53211
Country USA
 
Platforms (1)
GPL200 [Celegans] Affymetrix C. elegans Genome Array
Samples (47)
GSM1607548 GFP at T0, biological repeat 1
GSM1607549 GFP at T4, biological repeat 1
GSM1607550 GFP at T8, biological repeat 1
Relations
BioProject PRJNA275227

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE65851_RAW.tar 111.4 Mb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file
| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap