|
| Status |
Public on Jan 01, 2007 |
| Title |
mECK36: a cell and animal model of virally induced Kaposi's sarcoma |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Transfection of a Kaposi's sarcoma (KS) herpesvirus (KSHV) Bacterial Artificial Chromosome (KSHVBac36) into mouse bone marrow endothelial lineage cells generated a cell (mECK36) that induced KS-like tumors in mice. mECK36 formed KSHV-harboring vascularized spindle-cell sarcomas that were LANA+ and displayed a KSHV and host transcriptomes reminiscent of KS tumors.
Keywords: Cell type comparison
|
| |
|
| Overall design |
There are three biological replicates per sample. Tumors (mKS) were compared the the human KS signature. mECK36 and mEC-V were compared to putative BM lineage cells.
|
| |
|
| Contributor(s) |
Mesri E, Cavallin L |
| Citation(s) |
17349582, 22746102 |
| Submission date |
Dec 07, 2006 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Enrique Mesri |
| E-mail(s) |
emesri@med.miami.edu
|
| Phone |
305-243-5659
|
| Organization name |
University of Miami
|
| Department |
Microbiology and Immunology
|
| Street address |
1550 NW 10th Ave, PAP-109B
|
| City |
Miami |
| State/province |
FL |
| ZIP/Postal code |
33136 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
|
| Samples (9)
|
|
| Relations |
| BioProject |
PRJNA98727 |
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