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Series GSE61843 Query DataSets for GSE61843
Status Public on Mar 31, 2016
Title Inhibition of AK4 expression increases drug sensitivity and elevates mitochondrial ATP synthesis
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Adenylate kinase 4 (AK4) is localized in the mitochondrial matrix, and is believed to be involved in stress, drug resistance, the malignant transformation of cancer, and ATP regulation. We produced AK4 knockdown HeLa cells by using shRNA and used these to analyze resistance, and found that sensitivity to hypoxia and drugs increased.
Overall design 3 samples of HeLa cells haboring AK4 shRNA plasmids and 4 samples of HeLa cells haboring control shRNA plasmid.
Contributor(s) Fujisawa K, Terai S, Noma T, Takami T, Yamamoto N, Sakaida I
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Submission date Sep 29, 2014
Last update date Jan 09, 2018
Contact name Koichi Fujisawa
Organization name Yamaguchi University Graduate School of Medicine
Department Department of Gastroenterology and Hepatology
Street address 1-1-1, minami-kogushi
City Ube
State/province Yamaguchi
ZIP/Postal code 755-8505
Country Japan
Platforms (1)
GPL17077 Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
Samples (7)
GSM1515576 HeLa haboring control shRNA #1
GSM1515577 HeLa haboring control shRNA #2
GSM1515578 HeLa haboring control shRNA #3
BioProject PRJNA262546

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE61843_RAW.tar 86.7 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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