|
| Status |
Public on Mar 31, 2016 |
| Title |
Inhibition of AK4 expression increases drug sensitivity and elevates mitochondrial ATP synthesis |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Adenylate kinase 4 (AK4) is localized in the mitochondrial matrix, and is believed to be involved in stress, drug resistance, the malignant transformation of cancer, and ATP regulation. We produced AK4 knockdown HeLa cells by using shRNA and used these to analyze resistance, and found that sensitivity to hypoxia and drugs increased.
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| |
|
| Overall design |
3 samples of HeLa cells haboring AK4 shRNA plasmids and 4 samples of HeLa cells haboring control shRNA plasmid.
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| |
|
| Contributor(s) |
Fujisawa K, Terai S, Noma T, Takami T, Yamamoto N, Sakaida I |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Sep 29, 2014 |
| Last update date |
Jan 09, 2018 |
| Contact name |
Koichi Fujisawa |
| E-mail(s) |
fujisawa@yamaguchi-u.ac.jp
|
| Organization name |
Yamaguchi University Graduate School of Medicine
|
| Department |
Department of Gastroenterology and Hepatology
|
| Street address |
1-1-1, minami-kogushi
|
| City |
Ube |
| State/province |
Yamaguchi |
| ZIP/Postal code |
755-8505 |
| Country |
Japan |
| |
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| Platforms (1) |
| GPL17077 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version) |
|
| Samples (7)
|
|
| Relations |
| BioProject |
PRJNA262546 |
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