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Series GSE58015 Query DataSets for GSE58015
Status Public on May 28, 2014
Title Gene Expression Data in Human Monocyte-derived Dendritic Cell (MoDC) from Young and Aged Donors
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Dendritic cells (DCs) are major antigen-presenting cells that play a key role in initiating and regulating innate and adaptive immune responses. DCs are critical mediators of tolerance and immunity. The functional properties of DCs changes with age.
The purpose of this study was to define the age-associated molecular changes in DCs by gene array analysis using Affymatrix GeneChips. We identified up and down-regulated gene expression changes in DC from aged donors compared to young donors.
Overall design Total 9 MoDC RNA samples from four young donors (20-27 years) and five aged donors (77-84 years) were analyzed using Affymetrix HG-U133A_2 Gene Arrays to compare differential gene expression changes in MoDC between aged and young groups
Contributor(s) Cao J, Gupta S
Citation(s) 25191744
Submission date May 28, 2014
Last update date Dec 06, 2018
Contact name Sudhir Gupta
Organization name University of California, Irvine
Department Medicine
Lab Immunology
Street address Med Sci Buld I, C240
City Irvine
State/province CA
ZIP/Postal code 92697
Country USA
Platforms (1)
GPL571 [HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Samples (9)
GSM1399440 MoDC Young_1
GSM1399441 MoDC Young_2
GSM1399442 MoDC Young_3
BioProject PRJNA248715

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE58015_RAW.tar 17.8 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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