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Series GSE5788 Query DataSets for GSE5788
Status Public on Aug 27, 2007
Title Expression data from T-cell prolymphocytic leukemia (TPLL) and normal T cells
Organism Homo sapiens
Experiment type Expression profiling by array
Summary T-cell prolymphocytic leukemina (T-PLL) is an agressive lymphoma derived from mature T-cells, which is in most cases characterized by the presence of an inv(14)(q11q32) and a characteristic pattern of secondary chromosomal abberations.
We used microarrays to compare the transcriptomes of eight immunomagnetically purified CD3+ normal donor derived peripheral blood cells with five highly purified inv(14)-positive T-PLL blood samples.
Keywords: desease state analysis
Overall design Purified T-PLL cells and normal T-cells were analyzed on microarrays to identify differentially expressed genes. High-resolution copy number determination using SNP-chip technology and FISH in twelve inv(14)-positive T-PLL showed that differentially expressed genes clustered significantly in regions affectd by recurrent chromosomal imbalances.
Contributor(s) Dürig J, Bug S, Klein-Hitpass L, Boes T, Jöns T, Martin-Dubero JI, Harder L, Baudis M, Dührsen U, Siebert R
Citation(s) 17713554, 19750229
Submission date Sep 07, 2006
Last update date Mar 24, 2020
Contact name Ludger Klein-Hitpass
Phone +49 201 723 85552
Organization name Institut fuer Zellbiologie
Department Universitaetsklinikum
Lab BioChip Lab
Street address Virchowstr. 173
City Essen
ZIP/Postal code D-45122
Country Germany
Platforms (1)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
Samples (14)
GSM135264 T-cell prolymphocytic leukemia, inv(14)(q11q32), case 1
GSM135265 T-cell prolymphocytic leukemia, inv(14)(q11q32), case 2
GSM135266 T-cell prolymphocytic leukemia, inv(14)(q11q32), case 3
BioProject PRJNA97145

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Supplementary file Size Download File type/resource
GSE5788_RAW.tar 46.8 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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