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Series GSE57831 Query DataSets for GSE57831
Status Public on Nov 10, 2014
Title Profile of differential expression and DNA methylation status in choriodecidua of women affected with severe endometriosis [DNA methylation]
Organism Homo sapiens
Experiment type Methylation profiling by array
Summary Endometriosis is a common gynecological disease that affects 10-20% of women in child-bearing age. It is defined by the presence of endometrial tissues outside the uterus. The causes remain elusive, but the endometrium of these patients differs profoundly from that of disease-free subjects.
During pregnancy, the maternal-fetal interface is built onto decidualized endometrium. We investigated whether this interface is normal when the subjects suffer of endometriosis and showed remarkly properties of eutopic endometrium from endometriosis-affected women to spontaneously develop endometriotic-like lesions within direct contact to non-uterine tissues.
Overall design Methylation analysis was conducted on three distinct pools of three choriodecidua DNAs from women suffering of severe endometrosis and three distinct pools of healthy choriodecidua from eighteen pregnant women in total. These women were delivered at term by cesarean section for feto-pelvic disproportion or scarred uterus, after an uncomplicated pregnancy.
Contributor(s) Méhats C, Marcellin L
Citation(s) 25432921
Submission date May 20, 2014
Last update date Mar 22, 2019
Contact name Céline Méhats
Organization name Inserm
Department U1016
Street address 24 rue du Faubourg St jacques
City Paris
ZIP/Postal code 75014
Country France
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (6)
GSM1394742 DNA_methylation_CTRL_replicate_1
GSM1394743 DNA_methylation_CTRL_replicate_2
GSM1394744 DNA_methylation_CTRL_replicate_3
This SubSeries is part of SuperSeries:
GSE57832 Expression and methylation profiles of choriodecidua from pregnant women affected with deep endometriosis
BioProject PRJNA248205

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Supplementary file Size Download File type/resource
GSE57831_RAW.tar 183.1 Mb (http)(custom) TAR
GSE57831_unmethylated_methylated_intensities.txt.gz 26.3 Mb (ftp)(http) TXT
Processed data included within Sample table

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