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| Status |
Public on Jan 14, 2014 |
| Title |
Dextran sodium sulfate treatment of wild type and Pirc rats alters colonic normal tissue gene expression |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
Dextran sodium sulfate (DSS) causes inflammation in the gut similar to ulcerative colitis in humans. Patients with ulcerative colitis have increased risk of developing colon cancer. We sought to determine which genes are altered in the normal colonic epithelium, and which changes depend on the Pirc mutation.
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| Overall design |
97 day old (ACIxF344)F1 wild type and Pirc male rats either untreated or given 4% DSS in the drinking water from 40-47 and 54-61 days of age, housed in 12 hour light:12 dark, ad lib feeding. Normal colonic tissue was collected from the distal colon at 97 days of age.
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| Contributor(s) |
Irving AA, Dove WF |
| Citation(s) |
30188895 |
| |
| Submission date |
Jan 12, 2014 |
| Last update date |
Oct 29, 2018 |
| Contact name |
Amy Irving |
| Organization name |
University of Wisconsin-Madison
|
| Department |
McArdle Laboratory for Cancer Research
|
| Lab |
William Dove
|
| Street address |
1400 University Avenue
|
| City |
Madison |
| State/province |
WI |
| ZIP/Postal code |
53706 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL14797 |
Agilent-028279 SurePrint G3 Rat GE 8x60K Microarray (Feature Number version) |
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| Samples (16)
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| This SubSeries is part of SuperSeries: |
| GSE54036 |
Effects of dextran sodium sulfate on normal colonic tissue and tumors in wild type and Apc-Pirc/+ rats. |
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| Relations |
| BioProject |
PRJNA235285 |
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