|
| Status |
Public on Mar 07, 2014 |
| Title |
Expression profiling comparisons of human CD4+ T cells treated with RORgt inhibitors |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
The aim of this study was to identify differential gene expression resulting from the inhibition of RORgt in human CD4+ T cells.
|
| |
|
| Overall design |
Human CD4+ T cells were cultured with anti-CD3/anti-CD28 mAb for 20 to 60 hours concurrent with exposure to Vehicle (DMSO), TMP778 (0.2 uM) or TMP776 (0.2 uM). All samples were then processed for RNA extraction, labeling, and hybridization to Affymetrix arrays.
|
| |
|
| Contributor(s) |
Yang J, Skepner J, Remesh R |
| Citation(s) |
24516202 |
| |
| Submission date |
Dec 18, 2013 |
| Last update date |
Jul 26, 2018 |
| Contact name |
Scott Davis |
| Organization name |
GSK
|
| Department |
Tempero DPU
|
| Street address |
200 Technology Square, Suite 602
|
| City |
Cambridge |
| State/province |
MA |
| ZIP/Postal code |
02139 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
|
| Samples (20)
|
|
| Relations |
| BioProject |
PRJNA232048 |
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