|
| Status |
Public on Sep 21, 2014 |
| Title |
Gene expression profile of activated CD4 T cells from adults and newborns |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Given their precipitous encounter with the environment, newborn infants might be expected to possess abundant immunoprotective mechanisms. Paradoxically, their T cells display grossly impaired Th1 anti-bacterial and anti-viral responses. This study identifies factors produced by neonatal CD4 T cells when compared with adult naive CD4 T cells and highlights CXCL8 as a pivotal effector molecule in neonatal T cells. Using Affimetrix microarray we compared gene expression in cord blood derived CD4 T cells with naive CD4 T cells from adults after polyclonal stimulation.
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| |
|
| Overall design |
The Affymetrix GeneChip Human Genome 1.0 ST array were used to define gene expression profiles in each of the CD4 T cell samples.
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| |
|
| Contributor(s) |
Gibbons D, Hayday A |
| Citation(s) |
25242415 |
| |
| Submission date |
Nov 06, 2013 |
| Last update date |
Jul 26, 2018 |
| Contact name |
Deena L Gibbons |
| E-mail(s) |
deena.gibbons@kcl.ac.uk
|
| Organization name |
Kings College London
|
| Department |
Peter Gorer Department of Immunobiology
|
| Street address |
2nd Floor Borough Wing
|
| City |
London |
| State/province |
UK |
| ZIP/Postal code |
SE1 9RT |
| Country |
United Kingdom |
| |
|
| Platforms (1) |
| GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
|
| Samples (12)
|
| GSM1260083 |
Sorted CD38+ naive CD4 T cells from cord blood 1 |
| GSM1260084 |
Sorted CD38+ naive CD4 T cells from cord blood 2 |
| GSM1260085 |
Sorted CD38+ naive CD4 T cells from cord blood 3 |
| GSM1260086 |
Sorted CD38+ naive CD4 T cells from cord blood 4 |
| GSM1260087 |
Sorted CD38+ naive CD4 T cells from adult 1 |
| GSM1260088 |
Sorted CD38- naive CD4 T cells from adult 1 |
| GSM1260089 |
Sorted CD38+ naive CD4 T cells from adult 2 |
| GSM1260090 |
Sorted CD38- naive CD4 T cells from adult 2 |
| GSM1260091 |
Sorted CD38+ naive CD4 T cells from adult 3 |
| GSM1260092 |
Sorted CD38- naive CD4 T cells from adult 3 |
| GSM1260093 |
Sorted CD38+ naive CD4 T cells from adult 4 |
| GSM1260094 |
Sorted CD38- naive CD4 T cells from adult 4 |
|
| Relations |
| BioProject |
PRJNA226909 |
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