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| Status |
Public on Jul 31, 2013 |
| Title |
Investigation of Alterations in Gene Expression in the Retina Induced by Intravitreal Injection of gold and silicate nanoparticles |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
In this study, we investigated the gene expression induced by locally delivered gold and silicate nanoaprticles with the diameter of 20 and 100 nm in the retina. We injected nanoparticles into the vitreous cavity of 5-week-old male C57BL/6 mice. Au20 indicates gold nanoparticles of which diameters were 20 nm, Au100 gold nanoparticles of which diameters were 100 nm, Si20 silicate nanoparticles of which diameters were 20 nm, and Si100 silicate nanoparticles of which diameters were 100 nm.
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| Overall design |
We intravitreally injected PBS or nanoparticles (gold and silicate) into the right eyes of 5-week-old male C57BL/6 mice (n = 12 per group). PBS-treated mice were regarded as negative control. Four retinal tissues were pooled into 1 test tube and prepared for further analyses.
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| Contributor(s) |
Jo DH, Kim JH, Son JG, Lee TG, Kim JH |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Jul 30, 2013 |
| Last update date |
Nov 01, 2017 |
| Contact name |
Jeong Hun Kim |
| Organization name |
Seoul National University
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| Lab |
FARB (Fight against Angiogenesis-Related Blindness) Laboratory
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| Street address |
101, Daehak-ro, Jongno-gu
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| City |
Seoul |
| ZIP/Postal code |
110744 |
| Country |
South Korea |
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| Platforms (1) |
| GPL11202 |
Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA213733 |
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