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| Status |
Public on Nov 30, 2015 |
| Title |
Transcriptomic profiling in Malawian patients with acute hypersensitivity reactions to Nevirapine |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Nevirapine is a non-nucleoside reverse transcriptase inhibitor, a class of antiretroviral drug, used for the treatment of HIV-1 infection. Despite its wide use, nevirapine treatment has been associated with a significant incidence of different kind of hypersensitivity reactions (HSRs).
We used microarrays to find significant genes that can relate to Nevirapine-persuaded hypersensitivity reactions in ‘acute’ patients compared to ‘recovered’ and/or ‘tolerant’ patients.
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| Overall design |
We have selected 18 patients’ samples, 6 from each group (Acute, Recovered, Tolerant) to investigate Nevirapine induced hypersensitivity reactions using transcriptomic profiling based on microarray technology.
Acute:Patient taking nevirapine develops adverse drug reaction (ADR).
Recovered: 6 weeks after acute reaction-not longer taking nevirapine.
Tolerant: Patient on neviraoine and tolerating treatment.
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| Contributor(s) |
Mitra S, Bloch K, Chaponda M, Pirmohamed M |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Nov 21, 2012 |
| Last update date |
Jul 26, 2018 |
| Contact name |
Suparna Mitra |
| E-mail(s) |
suparna.mitra.sm@gmail.com, s.mitra@liverpool.ac.uk
|
| Organization name |
University of Liverpool
|
| Department |
Department of Molecular and Clinical Pharmacology
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| Lab |
Wolfson Centre for Personalised Medicine
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| Street address |
Block A: Waterhouse Buildings
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| City |
Liverpool |
| ZIP/Postal code |
L693GL |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (18)
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| Relations |
| BioProject |
PRJNA181968 |
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