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Series GSE40552 Query DataSets for GSE40552
Status Public on Nov 29, 2015
Title DBCP Exposed Rat Testis Transcript Content
Organism Rattus norvegicus
Experiment type Expression profiling by array
Summary Rats were exposed to sub-chronic low doses of the the germ cell toxicant 1,2-dibromo-3-chloropropane (DBCP) or corn oil (control for DBCP), for 3 months. Some rats in each group underwent 3 months of post-exposure recovery.
 
Overall design The apical endpoints and mating studies used in animal models for reproductive toxicity testing are not practical or translatable for human risk assessment, which typically focus on the analysis of semen and serum hormones. Because of these limitations, effort has been devoted to developing sperm molecular biomarkers that stably reflect male reproductive function. The goals of this work were to 1) identify biomarkers of testis damage within rat sperm after sub-chronic low dose exposures to the germ cell toxicant 1,2-dibromo-3-chloropropane [DBCP] for 3 months) using gene array analysis; and 2) compare these biomarkers to traditional endpoints.DBCP-treated rats had decreased body and epididymides weights, which also resolved after recovery, but no altered sperm transcripts.
 
Contributor(s) Pacheco SE, Boekelheide K
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Submission date Sep 03, 2012
Last update date Nov 29, 2015
Contact name Sara Pacheco
Organization name Brown University
Department Pathology and Lab Medicine
Lab Boekelheide
Street address 70 Ship Street, Room 510
City Providence
State/province RI
ZIP/Postal code 02903
Country USA
 
Platforms (1)
GPL6247 [RaGene-1_0-st] Affymetrix Rat Gene 1.0 ST Array [transcript (gene) version]
Samples (78)
GSM852347 DBCP, biological replicate 1
GSM852348 DBCP, biological replicate 2
GSM852349 DBCP, biological replicate 3
Relations
BioProject PRJNA174283

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Supplementary file Size Download File type/resource
GSE40552_RAW.tar 328.1 Mb (http)(custom) TAR (of CEL, CHP)
Processed data provided as supplementary file
Processed data included within Sample table
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