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Series GSE39899 Query DataSets for GSE39899
Status Public on Aug 01, 2015
Title Gene expression profiling in B lymphocytes from transplanted patients
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The achievement of a drug-free operational tolerance for renal transplanted patients is a major goal in organ transplantation. Previous gene expression profiling in peripheral blood mononuclear cells (PBMC) identified genes associated with operational tolerance. The identification of a common pattern of B cell-related genes associated with tolerance encourage us to analyze gene expression in purified B cell from operationally tolerant patients (TOL=10) compared to renal transplanted patients with stable graft function (STA=12) under immunosuppression and also compared to healthy volunteers (HV=10) who have no immunosuppressive treatment and no graft. Microarray analyses exhibited an absence of gene signature associated with tolerance in purified B cell compared to STA or HV. These results suggest that the B cell signatures observed in PBMC may be due to an increase number of total B cells rather than specific B cell characteristics in operationally tolerant patients.
Overall design This dataset represents gene expression profiling of purified B cells from 10 renal transplanted patients with operational tolerance (TOL), 12 renal transplanted patients with stable graft function under immunosuppression (STA) and 10 healthy volunteers (HV).
Contributor(s) Chesneau M, Danger R, Brouard S
Citation(s) 24354874
Submission date Aug 06, 2012
Last update date Nov 27, 2018
Contact name Richard Danger
Phone +33 2 40 08 75 65
Organization name CHU Nantes - INSERM- Nantes Universite
Department U1064
Street address 30 Boulevard Jean Monnet
City Nantes
ZIP/Postal code 44035
Country France
Platforms (1)
GPL13607 Agilent-028004 SurePrint G3 Human GE 8x60K Microarray (Feature Number version)
Samples (32)
GSM980947 HV-1
GSM980948 HV-10
GSM980949 HV-2
BioProject PRJNA172004

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE39899_RAW.tar 5.0 Mb (http)(custom) TAR
GSE39899_US82400123_252800413491_S01_GE2_107_Sep09_1_1.txt.gz 21.2 Mb (ftp)(http) TXT
GSE39899_US82400123_252800413491_S01_GE2_107_Sep09_1_2.txt.gz 21.2 Mb (ftp)(http) TXT
GSE39899_US82400123_252800413491_S01_GE2_107_Sep09_1_3.txt.gz 21.3 Mb (ftp)(http) TXT
GSE39899_US82400123_252800413491_S01_GE2_107_Sep09_1_4.txt.gz 21.3 Mb (ftp)(http) TXT
GSE39899_US82400123_252800413491_S01_GE2_107_Sep09_2_1.txt.gz 21.3 Mb (ftp)(http) TXT
GSE39899_US82400123_252800413491_S01_GE2_107_Sep09_2_2.txt.gz 21.3 Mb (ftp)(http) TXT
GSE39899_US82400123_252800413491_S01_GE2_107_Sep09_2_3.txt.gz 21.2 Mb (ftp)(http) TXT
GSE39899_US82400123_252800413491_S01_GE2_107_Sep09_2_4.txt.gz 21.2 Mb (ftp)(http) TXT
GSE39899_US82400123_252800413492_S01_GE2_107_Sep09_1_1.txt.gz 21.3 Mb (ftp)(http) TXT
GSE39899_US82400123_252800413492_S01_GE2_107_Sep09_1_2.txt.gz 21.3 Mb (ftp)(http) TXT
GSE39899_US82400123_252800413492_S01_GE2_107_Sep09_1_3.txt.gz 21.2 Mb (ftp)(http) TXT
GSE39899_US82400123_252800413492_S01_GE2_107_Sep09_1_4.txt.gz 21.3 Mb (ftp)(http) TXT
GSE39899_US82400123_252800413492_S01_GE2_107_Sep09_2_1.txt.gz 21.2 Mb (ftp)(http) TXT
GSE39899_US82400123_252800413492_S01_GE2_107_Sep09_2_2.txt.gz 21.3 Mb (ftp)(http) TXT
GSE39899_US82400123_252800413492_S01_GE2_107_Sep09_2_3.txt.gz 21.2 Mb (ftp)(http) TXT
GSE39899_US82400123_252800413492_S01_GE2_107_Sep09_2_4.txt.gz 21.2 Mb (ftp)(http) TXT
Processed data included within Sample table

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