|
| Status |
Public on Aug 01, 2015 |
| Title |
Gene expression profiling in B lymphocytes from transplanted patients |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
The achievement of a drug-free operational tolerance for renal transplanted patients is a major goal in organ transplantation. Previous gene expression profiling in peripheral blood mononuclear cells (PBMC) identified genes associated with operational tolerance. The identification of a common pattern of B cell-related genes associated with tolerance encourage us to analyze gene expression in purified B cell from operationally tolerant patients (TOL=10) compared to renal transplanted patients with stable graft function (STA=12) under immunosuppression and also compared to healthy volunteers (HV=10) who have no immunosuppressive treatment and no graft. Microarray analyses exhibited an absence of gene signature associated with tolerance in purified B cell compared to STA or HV. These results suggest that the B cell signatures observed in PBMC may be due to an increase number of total B cells rather than specific B cell characteristics in operationally tolerant patients.
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| |
|
| Overall design |
This dataset represents gene expression profiling of purified B cells from 10 renal transplanted patients with operational tolerance (TOL), 12 renal transplanted patients with stable graft function under immunosuppression (STA) and 10 healthy volunteers (HV).
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| |
|
| Contributor(s) |
Chesneau M, Danger R, Brouard S |
| Citation(s) |
24354874 |
| Submission date |
Aug 06, 2012 |
| Last update date |
Nov 27, 2018 |
| Contact name |
Richard Danger |
| E-mail(s) |
richard.danger@univ-nantes.fr
|
| Phone |
+33 2 40 08 75 65
|
| Organization name |
CHU Nantes - INSERM- Nantes Universite
|
| Department |
U1064
|
| Lab |
CR2TI
|
| Street address |
30 Boulevard Jean Monnet
|
| City |
Nantes |
| ZIP/Postal code |
44035 |
| Country |
France |
| |
|
| Platforms (1) |
| GPL13607 |
Agilent-028004 SurePrint G3 Human GE 8x60K Microarray (Feature Number version) |
|
| Samples (32)
|
|
| Relations |
| BioProject |
PRJNA172004 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE39899_RAW.tar |
5.0 Mb |
(http)(custom) |
TAR |
| GSE39899_US82400123_252800413491_S01_GE2_107_Sep09_1_1.txt.gz |
21.2 Mb |
(ftp)(http) |
TXT |
| GSE39899_US82400123_252800413491_S01_GE2_107_Sep09_1_2.txt.gz |
21.2 Mb |
(ftp)(http) |
TXT |
| GSE39899_US82400123_252800413491_S01_GE2_107_Sep09_1_3.txt.gz |
21.3 Mb |
(ftp)(http) |
TXT |
| GSE39899_US82400123_252800413491_S01_GE2_107_Sep09_1_4.txt.gz |
21.3 Mb |
(ftp)(http) |
TXT |
| GSE39899_US82400123_252800413491_S01_GE2_107_Sep09_2_1.txt.gz |
21.3 Mb |
(ftp)(http) |
TXT |
| GSE39899_US82400123_252800413491_S01_GE2_107_Sep09_2_2.txt.gz |
21.3 Mb |
(ftp)(http) |
TXT |
| GSE39899_US82400123_252800413491_S01_GE2_107_Sep09_2_3.txt.gz |
21.2 Mb |
(ftp)(http) |
TXT |
| GSE39899_US82400123_252800413491_S01_GE2_107_Sep09_2_4.txt.gz |
21.2 Mb |
(ftp)(http) |
TXT |
| GSE39899_US82400123_252800413492_S01_GE2_107_Sep09_1_1.txt.gz |
21.3 Mb |
(ftp)(http) |
TXT |
| GSE39899_US82400123_252800413492_S01_GE2_107_Sep09_1_2.txt.gz |
21.3 Mb |
(ftp)(http) |
TXT |
| GSE39899_US82400123_252800413492_S01_GE2_107_Sep09_1_3.txt.gz |
21.2 Mb |
(ftp)(http) |
TXT |
| GSE39899_US82400123_252800413492_S01_GE2_107_Sep09_1_4.txt.gz |
21.3 Mb |
(ftp)(http) |
TXT |
| GSE39899_US82400123_252800413492_S01_GE2_107_Sep09_2_1.txt.gz |
21.2 Mb |
(ftp)(http) |
TXT |
| GSE39899_US82400123_252800413492_S01_GE2_107_Sep09_2_2.txt.gz |
21.3 Mb |
(ftp)(http) |
TXT |
| GSE39899_US82400123_252800413492_S01_GE2_107_Sep09_2_3.txt.gz |
21.2 Mb |
(ftp)(http) |
TXT |
| GSE39899_US82400123_252800413492_S01_GE2_107_Sep09_2_4.txt.gz |
21.2 Mb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
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