|
| Status |
Public on Jun 06, 2012 |
| Title |
Placental gene expression in pregnancies established after the transfer of day 7 blastocysts derived from in vitro (IVP), somatic cell nuclear transfer (SCNT) and in vivo (AI) embryos |
| Organism |
Bos taurus |
| Experiment type |
Expression profiling by array
|
| Summary |
Aberrant placental gene expression associated with culture condition and/or deficiencies in transcriptome reprogramming are hypothesized to be the major cause of SCNT and IVP inefficiencies. Therefore, the main objective of this study was to invesitgate the dysregulated genes, molecular pathways and functional alteration in bovine placentas derived from SCNT and IVP pregnancies compared to their AI counterparts
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| |
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| Overall design |
Day 7 blastocysts derived from AI, IVP or SCNT were transferred to synchronized cows. The pregnant animals were slaughtered at day 50 of the gestation period and the placentas were then recovered and used for transcriptome analysis using GeneChip bovine genome array
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| Contributor(s) |
Salilew-Wondim D, Tesfaye D, Hossain MM, Held E, Rings F, Tholen E, Looft C, Schellander K, Hoelker M |
| Citation(s) |
23092953 |
| |
| Submission date |
Jun 05, 2012 |
| Last update date |
Feb 05, 2013 |
| Contact name |
Dessie Salilew-Wondim |
| E-mail(s) |
dsalilew@uni-bonn.de
|
| Organization name |
University of Bonn
|
| Department |
Animal breeding and husbandry group
|
| Street address |
Endenicher Allee 15
|
| City |
Bonn |
| State/province |
NRW |
| ZIP/Postal code |
D-53115 |
| Country |
Germany |
| |
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| Platforms (1) |
| GPL2112 |
[Bovine] Affymetrix Bovine Genome Array |
|
| Samples (12)
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| Relations |
| BioProject |
PRJNA168092 |
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