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| Status |
Public on Jul 12, 2012 |
| Title |
ATFS-1 mediates a protective transcription program during mitochondrial stress |
| Organism |
Caenorhabditis elegans |
| Experiment type |
Expression profiling by array
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| Summary |
ATFS-1 has been shown to regulate transcription of mitochondrial chaperone genes such as mtHsp70/hsp-6 and hsp-60 in response to mitocondrial stress. To identify the entire ATFS-1-mediated response, we compared the transcript profiles from wild-type and atfs-1(tm4525) worms raised in the absence and presence of mitochondrial stress.
We used microarrays to identify genes regulated by ATFS-1 during mitochondrial stress
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| Overall design |
RNA samples were prepared from wild-type(wt) and atfs-1(tm4525)(mutant) worms fed either control(RNAi) or spg-7(RNAi). Worms were synchronized by bleaching, raised in liquid culture and harvested at the L4 stage. Control is denoted as C and spg-7 treatment is denoted T. Each experiment was performed in triplicate indicated as 1,2 and 3.
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| Contributor(s) |
Nargund A, Haynes C |
| Citation(s) |
22700657 |
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| Submission date |
May 23, 2012 |
| Last update date |
Jul 06, 2016 |
| Contact name |
Jeffrey Zhao |
| Organization name |
Memorial Sloan Kettering Cancer Center
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| Department |
Genomics Core
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| Street address |
1275 York Avenue
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| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10065 |
| Country |
USA |
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| Platforms (1) |
| GPL200 |
[Celegans] Affymetrix C. elegans Genome Array |
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| Samples (12)
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| GSM936472 |
wild-type-control, biological rep1 |
| GSM936473 |
wild-type-treated, biological rep1 |
| GSM936474 |
atfs-1(tm4525)-control, biological rep1 |
| GSM936475 |
atfs-1(tm4525)-treated, biological rep1 |
| GSM936476 |
wild-type-control, biological rep2 |
| GSM936477 |
wild-type-treated, biological rep2 |
| GSM936478 |
atfs-1(tm4525)-control, biological rep2 |
| GSM936479 |
atfs-1(tm4525)-treated, biological rep2 |
| GSM936480 |
wild-type-control, biological rep3 |
| GSM936481 |
wild-type-treated, biological rep3 |
| GSM936482 |
atfs-1(tm4525)-control, biological rep3 |
| GSM936483 |
atfs-1(tm4525)-treated, biological rep3 |
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| Relations |
| BioProject |
PRJNA167341 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE38196_RAW.tar |
25.2 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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