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| Status |
Public on Dec 31, 2013 |
| Title |
Gene expression analysis of recurrent metastatic melanoma lesions |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
In this study, we sought to indentify stable individual traits in developing metastatic melanoma, assess their stability in time, and analyze typical dynamics and common trends of genomic changes in individual cases of late stage metastatic cancer.
To this end, we compared consecutive recurrent metastases developed by a special group of eight individuals with advanced metastatic melanoma, all developing several recurrent metastases over several months to years of natural disease evolution.
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| Overall design |
Twenty-six recurrent melanoma metastases were surgically isolated from 8 patients experiencing relapse after one or more successful treatment intervention(s) with no signs of residual disease. Patients experiencing recurrent metastases were labeled with capital letters; “A”, “B”, “C”, etc., their subsequent metastases as “A/1”, “A/2”, “B/1”, “B/2”, etc., while synchronous metastases in a given patient were labeled as “A/1a”, “A/1b” etc. Another 22 melanoma cell lines isolated and maintained as above were expanded from melanoma patients with rapid disease curse, for whom only one metastasis was available. As no extended follow up was possible in these cases, the cell lines are considered representative of random time points in the natural course of metastatic melanoma. These cell lines were labeled with Arabic numbers, as “1”, “2”, ”3”, etc
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| Contributor(s) |
Pos Z, Spivey TL, Liu H, Chen J, Maio M, Robbins PF, Wang E, Marincola FM |
| Citation(s) |
24270663 |
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| Submission date |
May 22, 2012 |
| Last update date |
Jul 26, 2018 |
| Contact name |
Zoltan Pos |
| E-mail(s) |
pos.zoltan@outlook.com.com
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| Phone |
+(36)12102930-56435
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| Organization name |
Semmelweis University
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| Department |
Dept. of Genetics, Cell- and Immunobiology
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| Street address |
4 Nagyvarad ter
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| City |
Budapest |
| ZIP/Postal code |
H-1089 |
| Country |
Hungary |
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| Platforms (1) |
| GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (48)
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| GSM934837 |
Recurrent melanoma patient A, 1st recurrence |
| GSM934838 |
Recurrent melanoma patient A, 2nd recurrence, 1st synchronous lesion |
| GSM934839 |
Recurrent melanoma patient A, 2nd recurrence, 2nd synchronous lesion |
| GSM934840 |
Recurrent melanoma patient A, 3rd recurrence, 1st synchronous lesion |
| GSM934841 |
Recurrent melanoma patient A, 3rd recurrence, 2nd synchronous lesion |
| GSM934842 |
Recurrent melanoma patient A, 3rd recurrence, 3rd synchronous lesion |
| GSM934843 |
Recurrent melanoma patient A, 4th recurrence |
| GSM934844 |
Recurrent melanoma patient B, 1st recurrence |
| GSM934845 |
Recurrent melanoma patient B, 2nd recurrence |
| GSM934846 |
Recurrent melanoma patient C, 1st recurrence |
| GSM934847 |
Recurrent melanoma patient C, 2nd recurrence |
| GSM934848 |
Recurrent melanoma patient C, 3rd recurrence |
| GSM934849 |
Recurrent melanoma patient D, 1st recurrence |
| GSM934850 |
Recurrent melanoma patient D, 2nd recurrence |
| GSM934851 |
Recurrent melanoma patient E, 1st recurrence |
| GSM934852 |
Recurrent melanoma patient E, 2nd recurrence |
| GSM934853 |
Recurrent melanoma patient E, 3rd recurrence |
| GSM934854 |
Recurrent melanoma patient F, 1st recurrence |
| GSM934855 |
Recurrent melanoma patient F, 2nd recurrence |
| GSM934856 |
Recurrent melanoma patient F, 3rd recurrence |
| GSM934857 |
Recurrent melanoma patient G, 1st recurrence |
| GSM934858 |
Recurrent melanoma patient G, 2nd recurrence |
| GSM934859 |
Recurrent melanoma patient G, 3rd recurrence |
| GSM934860 |
Recurrent melanoma patient H, 1st recurrence |
| GSM934861 |
Recurrent melanoma patient H, 2nd recurrence |
| GSM934862 |
Recurrent melanoma patient H, 3rd recurrence |
| GSM934863 |
Random melanoma patient 1 |
| GSM934864 |
Random melanoma patient 2 |
| GSM934865 |
Random melanoma patient 3 |
| GSM934866 |
Random melanoma patient 4 |
| GSM934867 |
Random melanoma patient 5 |
| GSM934868 |
Random melanoma patient 6 |
| GSM934869 |
Random melanoma patient 7 |
| GSM934870 |
Random melanoma patient 8 |
| GSM934871 |
Random melanoma patient 9 |
| GSM934872 |
Random melanoma patient 10 |
| GSM934873 |
Random melanoma patient 11 |
| GSM934874 |
Random melanoma patient 12 |
| GSM934875 |
Random melanoma patient 13 |
| GSM934876 |
Random melanoma patient 14 |
| GSM934877 |
Random melanoma patient 15 |
| GSM934878 |
Random melanoma patient 16 |
| GSM934879 |
Random melanoma patient 17 |
| GSM934880 |
Random melanoma patient 18 |
| GSM934881 |
Random melanoma patient 19 |
| GSM934882 |
Random melanoma patient 20 |
| GSM934883 |
Random melanoma patient 21 |
| GSM934884 |
Random melanoma patient 22 |
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| This SubSeries is part of SuperSeries: |
| GSE38187 |
Gene expression and copy number analysis of recurrent metastatic melanoma lesions |
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| Relations |
| BioProject |
PRJNA167385 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE38119_RAW.tar |
201.4 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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