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| Status |
Public on Apr 30, 2012 |
| Title |
Erythroid-Specific Transcriptional Changes in PBMCs from Pulmonary Hypertension Patients |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
The hypothesis tested in this study was that chronic exposure of PBMCs to a hypertensive environment in remodeled pulmonary vessels would be reflected by specific transcriptional changes in these cells.
The transcript profiles of PBMCs from 30 idiopathic pulmonary arterial hypertension patients (IPAH), 19 patients with systemic sclerosis without pulmonary hypertension (SSc), 42 scleroderma-associated PAH patients (SSc-PAH), and 8 patients with SSc complicated by interstitial lung disease and PH (SSC-PH-ILD) were compared to the gene expression profiles of PBMCs from 41 healthy individuals.
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| |
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| Overall design |
Gene expression is compared at a global level using total RNA from BPMC for pateints and controls using the Illumina microarray platform.
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| |
|
| Contributor(s) |
Cheadle C, Alan B |
| Citation(s) |
22545094 |
| |
| Submission date |
Nov 03, 2011 |
| Last update date |
Mar 25, 2020 |
| Contact name |
chris cheadle |
| E-mail(s) |
ccheadl1@jhmi.edu
|
| Phone |
4105505984
|
| Organization name |
JHU
|
| Department |
SOM
|
| Lab |
JHBMC Genomics Core
|
| Street address |
5200 Eastern Ave
|
| City |
baltimore |
| State/province |
MD |
| ZIP/Postal code |
21224 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL6947 |
Illumina HumanHT-12 V3.0 expression beadchip |
|
| Samples (140)
|
|
| Relations |
| BioProject |
PRJNA148779 |
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