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| Status |
Public on Apr 17, 2024 |
| Title |
Shared Transcriptomic Signatures of Inflammaging Among Diverse Strains of Drosophila melanogaster |
| Organism |
Drosophila melanogaster |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Background: A prominent hallmark of aging is inflammaging—the increased expression of innate immune genes without identifiable infection. Model organisms with shorter lifespans, such as the fruit fly, provide an essential platform for probing the mechanisms of inflammaging. Multiple groups have reported that, like mammalian models, old flies have significantly higher levels of expression of anti-microbial peptide genes. However, whether some of these genes—or any others—can serve as reliable markers for assessing and comparing inflammaging in different strains remains unclear. Methods and Results: We compared RNA-Seq datasets generated by different groups. Although the fly strains used in these studies differ significantly, we found that they share a core group of genes with strong aging-associated expression. In addition to anti-microbial peptide genes, we identified other genes that have prominently increased expression in old flies, especially SPH93. We further showed that machine learning models can be used to predict the “inflammatory age” of the fruit fly.
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| Overall design |
Fruit flies were aged in 25 to designated age and processed for RNA extraction.
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| Contributor(s) |
Perna SI, Tang W, Li A, Blimbaum SD, Zhou L |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Mar 28, 2024 |
| Last update date |
Apr 17, 2024 |
| Contact name |
Lei Zhou |
| E-mail(s) |
leizhou@ufl.edu
|
| Phone |
3522738169
|
| Organization name |
University of Florida
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| Department |
Molecular Genetics and Microbiology
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| Lab |
Zhou
|
| Street address |
PO Box 100266
|
| City |
Gainesville |
| State/province |
FL |
| ZIP/Postal code |
32610 |
| Country |
USA |
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| Platforms (1) |
| GPL19132 |
Illumina NextSeq 500 (Drosophila melanogaster) |
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| Samples (50)
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| Relations |
| BioProject |
PRJNA1093126 |
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