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Series GSE261891

Query DataSets for GSE261891

Status

Public on May 31, 2024

Title

Contribution of DNA methylation profiling in the classification of TRIO::TERT sarcomas

Organism

Homo sapiens

Experiment type

Genome variation profiling by SNP array

Summary

DNA methylation profiling has emerged as a valuable tool for tumor classification, exemplified by the German Cancer Research Center's creation of online classifiers for CNS tumors and sarcomas. Identification of rare molecular events, such as TRIO::TERT fusion in undifferentiated sarcomas, through DNA methylation profiling and transcriptome analysis aims to define distinct molecular subgroups within sarcomas of uncertain diagnosis, potentially improving classification and treatment strategies.In this study, we present 8 cases of sarcomas characterized by TRIO::TERT fusion, establishing it as a distinct molecular subtype of sarcomas. This fusion represents a consistent molecular feature across all analyzed tumors, suggesting its pivotal role in sarcomatogenesis. Identifying TRIO::TERT transcript sarcoma as a new tumor type may enhance diagnostic strategies for improved patient management.

Overall design

screening of 5 cases of TRIO-TERT sarcoma by SNP array with affymetrix platform

Contributor(s)

Paoli C, Sievers P, Tirode F, Pissaloux D, Karanian M, Monticelli I, Hasselblatt M, Boyer J, Saada-Bouzid E, Burel-Vandenbos F, Dadone-Montaudié B

Citation missing

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Submission date

Mar 19, 2024

Last update date

May 31, 2024

Contact name

Ilaria Di Mauro