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| Status |
Public on Jul 05, 2024 |
| Title |
Gene expression of alveolar macrophage in mice with AT2 cell-specific Cpt1a deletion |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Carnitine palmitoyltransferase 1a (CPT1a) is the key regulator of mitochondrial long-chain fatty acid beta-oxidation (LCFAO). However, the functional significance of AT2 cell-specific LCFAO at baseline and during acute lung injury (ALI) is not fully understood. In this study, Murine models of AT2 cell-specific Cpt1a deletion were generated for investigating the role of CPT1a in regulating AT2 cell function and the severity of lipopolysaccharide-induced murine ALI models.
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| Overall design |
To investigate whether impaired LCFAO in AT2 cells regulates the responses of alveolar macrophages, we also isolated alveolar macrophages from Cpt1a-KO and control mice for trancriptomic analysis.
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| Contributor(s) |
Chung K |
| Citation(s) |
39174557 |
| |
| Submission date |
Feb 16, 2024 |
| Last update date |
Sep 27, 2024 |
| Contact name |
Chia-Lang Hsu |
| E-mail(s) |
chialanghsu@ntuh.gov.tw
|
| Organization name |
National Taiwan University Hospital
|
| Department |
Department of Medical Research
|
| Street address |
No. 7, Zhongshan S. Rd.
|
| City |
Taipei |
| ZIP/Postal code |
100 |
| Country |
Taiwan |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (11)
|
| GSM8083254 |
Alveolar macrophages from control mouse (sample #1) |
| GSM8083255 |
Alveolar macrophages from control mouse (sample #2) |
| GSM8083256 |
Alveolar macrophages from control mouse (sample #3) |
| GSM8083257 |
Alveolar macrophages from control mouse (sample #4) |
| GSM8083258 |
Alveolar macrophages from control mouse (sample #5) |
| GSM8083259 |
Alveolar macrophages from Cpt1a-KO mouse (sample #1) |
| GSM8083260 |
Alveolar macrophages from Cpt1a-KO mouse (sample #2) |
| GSM8083261 |
Alveolar macrophages from Cpt1a-KO mouse (sample #3) |
| GSM8083262 |
Alveolar macrophages from Cpt1a-KO mouse (sample #4) |
| GSM8083263 |
Alveolar macrophages from Cpt1a-KO mouse (sample #5) |
| GSM8083264 |
Alveolar macrophages from Cpt1a-KO mouse (sample #6) |
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| Relations |
| BioProject |
PRJNA1077286 |
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