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| Status |
Public on Apr 11, 2024 |
| Title |
RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We performed bulk RNA-seq analysis for CRISPR-Cpf1 mutated H1 cells that were differentiated into pancreatic cells. Homozygous mutant was compared to control cells (RFX6-/- vs RFX6+/+) at stage 3 (PF) and stage 5 (EP), and heterozygous mutant was compared to control cells (RFX6-/+ vs RFX6+/+) at stage 7 (SC-islets).
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| Overall design |
RNA-seq
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| Contributor(s) |
Ibrahim H, Balboa D, Saarimäki-Vire J, Montaser H, Dyachok O, Lund P, Omar-Hmeadi M, Kvist J, Dwivedi OP, Lithovius V, Barsby T, Chandra V, Eurola S, Ustinov J, Tuomi T, Miettinen PJ, Barg S, Tengholm A, Otonkoski T |
| Citation(s) |
38743124 |
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| Submission date |
Jun 06, 2023 |
| Last update date |
Jul 12, 2024 |
| Contact name |
Jouni Antero Kvist |
| Organization name |
University of Helsinki
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| Department |
Research Program for Molecular Neurology
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| Lab |
Medical Neurogenetics group
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| Street address |
Haartmaninkatu 8
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| City |
Helsinki |
| State/province |
Uusimaa |
| ZIP/Postal code |
00014 |
| Country |
Finland |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (24)
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| Relations |
| BioProject |
PRJNA980693 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE234289_DE_results.csv.gz |
4.9 Mb |
(ftp)(http) |
CSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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