|
| Status |
Public on May 14, 2024 |
| Title |
Single cell RNA sequencing for α lymphoid progenitor |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The single-cell transcriptional analysis of bone marrow progenitors and subsequent analysis revealed that GATA3 induction in late ILC2-committed precursor depends on the G3SE lesion and that the upregulation of GATA3 in the late ILC2-precursor is required for the transition to mature ILC2.
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| |
|
| Overall design |
Single cell RNA-sequencing was performed in α lymphoid progenitor of WT mice and G3SEKO (GATA3-related tandem Super-Enhancers Knock-Out) mice
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| |
|
| Contributor(s) |
Iwata A, Furuya H, Toda Y |
| Citation(s) |
38969652 |
| |
| Submission date |
Nov 16, 2022 |
| Last update date |
Jul 17, 2024 |
| Contact name |
Arifumi Iwata |
| Organization name |
Chiba University
|
| Department |
Department of Allergy and Clinical Immunology
|
| Street address |
1-8-1 Inohana, Chuou-ku
|
| City |
Chiba-shi |
| State/province |
Chiba |
| ZIP/Postal code |
260-8670 |
| Country |
Japan |
| |
|
| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
|
| Samples (4)
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| This SubSeries is part of SuperSeries: |
| GSE218155 |
ILC2 development requires GATA3-related super-enhancers after lineage commitment |
|
| Relations |
| BioProject |
PRJNA902422 |
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