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| Status |
Public on Sep 01, 2010 |
| Title |
Breast Carcinomas arising at a Young Age: A Unique Biology or a Surrogate for Aggressive Intrinsic Subtypes. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Breast cancer is no longer viewed as a homogenous disease, but rather a compilation of several distinct subtypes as defined by microarray or other large scale genomic analyses. Based on prior reports, we hypothesized that younger women’s breast tumors would be enriched for more aggressive subtypes (i.e. Basal-like) and higher grade, and that age-specific gene expression differences may be highly dependent on subtype classification and/or grade. Using two independent datasets, our current analysis shows that breast tumors arising in women aged = 45 years are enriched for the Basal-like subtype (and higher grade) while those aged = 65 years are enriched for Luminal tumors. Moreover, when evaluating gene expression differences between age-defined groups, sizable gene lists were identified which diminished to few, if any, age-specific genes when statistically correcting for significant clinical factors (i.e. subtype, grade, etc).
Keywords: reference x sample
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| |
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| Overall design |
344 breast tumor samples hybridized with Stratagene common reference and profiled on Agilent microarrays.
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| |
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| Contributor(s) |
Anders CK, Perou CM |
| Citation(s) |
21115855 |
| |
| Submission date |
Mar 04, 2010 |
| Last update date |
Nov 17, 2017 |
| Contact name |
Charles M. Perou |
| E-mail(s) |
cperou@med.unc.edu
|
| Organization name |
University of North Carolina at Chapel Hill
|
| Department |
Professor of Genetics, and Pathology & Laboratory Medicine; Lineberger Comprehensive Cancer Center
|
| Street address |
12-044 Lineberger Comprehensive Cancer Center CB# 7295
|
| City |
Chapel Hill |
| State/province |
NC |
| ZIP/Postal code |
27599-7264 |
| Country |
USA |
| |
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| Platforms (4)
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| GPL885 |
Agilent-011521 Human 1A Microarray G4110A (Feature Number version) |
| GPL887 |
Agilent-012097 Human 1A Microarray (V2) G4110B (Feature Number version) |
| GPL1390 |
Agilent Human 1A Oligo UNC custom Microarrays |
| GPL5325 |
Agilent UNC Perou Lab Homo sapiens 1X44K Custom Array |
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| Samples (344)
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| Relations |
| BioProject |
PRJNA124813 |
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