|
| Status |
Public on Nov 07, 2021 |
| Title |
Evolution of Natural Lifespan Variation and Molecular Strategies of Extended Lifespan |
| Organisms |
Saccharomyces cerevisiae; Saccharomyces paradoxus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Here, we analyzed 76 ecologically diverse wild yeast isolates and discovered a wide diversity of replicative lifespan. Phylogenetic analyses pointed to genes and environmental factors that strongly interact to modulate the observed aging patterns. We then identified genetic networks causally associated with natural variation in replicative lifespan across wild yeast isolates, as well as genes, metabolites and pathways, many of which have never been associated with yeast lifespan in laboratory settings. In addition, a combined analysis of lifespan-associated metabolic and transcriptomic changes revealed unique adaptations to interconnected amino acid biosynthesis, glutamate metabolism and mitochondrial function in long-lived strains. Overall, our multi-omic and lifespan analyses across diverse isolates of the same species shows how gene-environment interactions shape cellular processes involved in phenotypic variation such as lifespan.
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| |
|
| Overall design |
Examination of gene expression changes across lifespans of 76 wild yeast isolates.
|
| Web link |
https://pubmed.ncbi.nlm.nih.gov/34751131/
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| |
|
| Contributor(s) |
Kaya A, Ma S, Zhou X |
| Citation(s) |
34751131 |
| |
| Submission date |
Nov 05, 2021 |
| Last update date |
Nov 11, 2021 |
| Contact name |
Alaattin Kaya |
| E-mail(s) |
kayaa@vcu.edu
|
| Organization name |
Virginia Commonwealth University
|
| Department |
Biology
|
| Lab |
kayalab
|
| Street address |
1000 West Carry St, Room 126
|
| City |
Richmond |
| State/province |
VA |
| ZIP/Postal code |
23284 |
| Country |
USA |
| |
|
| Platforms (2) |
| GPL21656 |
Illumina HiSeq 4000 (Saccharomyces cerevisiae) |
| GPL30932 |
Illumina HiSeq 4000 (Saccharomyces paradoxus) |
|
| Samples (226)
|
|
| Relations |
| BioProject |
PRJNA778214 |
| SRA |
SRP344789 |
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