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| Status |
Public on Jan 01, 2010 |
| Title |
Expression from C. elegans L1 animals |
| Organism |
Caenorhabditis elegans |
| Experiment type |
Expression profiling by array
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| Summary |
Nutrient-driven O-GlcNAcylation of key components of the transcription machinery may epigenetically modulate gene expression in metazoans. Knockouts of the O-GlcNAc cycling enzymes in C. elegans are viable and fertile, allowing a global analysis of the impact of GlcNAcylation.
Whole genome transcriptional profiling of the O-GlcNAc cycling mutants confirmed dramatic deregulation of genes in these key pathways. As predicted, the O-GlcNAc cycling mutants show phenotypically altered lifespan and susceptibility to UV stress.
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| Overall design |
L1 larvae were synchronized by starvation for two days after hatching in sterile buffer. Wild type and mutant animals were collected and total RNA isolated for gene expression analysis
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| Contributor(s) |
Krause M, Hanover J |
| Citation(s) |
20368426, 30250452 |
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| Submission date |
Sep 16, 2009 |
| Last update date |
Jun 11, 2019 |
| Contact name |
Michael Krause |
| E-mail(s) |
mwkrause@helix.nih.gov
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| Phone |
(301) 402-4633
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| Organization name |
NIH
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| Department |
LMB/NIDDK
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| Lab |
Krause
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| Street address |
5 Center Drive
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| City |
Bethesda |
| State/province |
MD |
| ZIP/Postal code |
20892 |
| Country |
USA |
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| Platforms (1) |
| GPL200 |
[Celegans] Affymetrix C. elegans Genome Array |
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| Samples (9)
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| GSM453401 |
Ogt starved L1, biological replicate 1 |
| GSM453402 |
Ogt starved L1, biological replicate 2 |
| GSM453403 |
Ogt starved L1, biological replicate 3 |
| GSM453404 |
Oga starved L1, biological replicate 1 |
| GSM453405 |
Oga starved L1, biological replicate 2 |
| GSM453406 |
Oga starved L1, biological replicate 3 |
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| This SubSeries is part of SuperSeries: |
| GSE18132 |
Dynamic O-GlcNAc cycling at promoters of C. elegans genes regulating Longevity, Stress, and Immunity |
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| Relations |
| BioProject |
PRJNA123475 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE18130_RAW.tar |
88.3 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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