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| Status |
Public on May 15, 2021 |
| Title |
Anti-aging effect of olmesartan on miRNA expression profile in smooth muscle cells |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by high throughput sequencing
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| Summary |
High-throughput sequencing technique was used to screen the miRNAs which has potential role in the aging delaying effect of olmesartan on human smooth muscle cells. We cultured human vascular smooth muscle cells and used the third to fifth generation cells as unaging cells (Zhengchang-1,-2,-3), natural culture to passage 10 to 15 as aging group samples (Bo-1,-2,-3), and cells treated with olmesartan for the same time as aging group cells as treatment group (bo-ao-1,-2,-3). After collecting cells of each group, RNA was extracted and reversed. After the quality inspection was qualified, miRNA sequencing was carried out. Finally, we confirmed that the miRNA expression profile of human vascular smooth muscle cells changed after olmesartan treatment. This study confirmed that miRNA plays a potential role in the aging process of human smooth muscle cells and that olmesartan may play a role in delaying aging by regulating miRNA expression profile.
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| Overall design |
Examination the miRNAs profiles in Olmesartan-treated human Senescent VSMCs
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| Contributor(s) |
Zhang L |
| Citation(s) |
34386495 |
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| Submission date |
May 14, 2021 |
| Last update date |
Aug 18, 2021 |
| Contact name |
Li Zhang |
| E-mail(s) |
zhangli4029@126.com
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| Organization name |
The First Affiliated Hospital of Guangdong Pharmaceutical University
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| Street address |
No. 19, Nonglinxia Road
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| City |
Guangzhou |
| State/province |
Guangdong |
| ZIP/Postal code |
510080 |
| Country |
China |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA729993 |
| SRA |
SRP319931 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE174451_miRNA_expression.txt.gz |
70.9 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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