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| Status |
Public on Feb 27, 2022 |
| Title |
Transcriptome analysis of human induced liver cancer-forming cells (iLCCs) , HepG2 cells, Huh6 cells, Huh7 cells, and HuCCT1 cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We found that a set of six transcription factors, FOXA3, HNF1A, HNF1B, LIN28B, L-MYC, and KLF5, can induce direct conversion of human umbilical vein endothelial cells (HUVECs) into liver cancer-forming cells (LCCs). These induced LCCs (iLCCs) efficiently arise tumors that closely resemble human combined hepatocellular cholangiocarcinoma after transplantation. We conducted 3' untranslated region (UTR)-seq (RNA-seq) analyses to investigate the characteristincs of iLCCs, HepG2 cells, Huh6 cells, Huh7 cells, and HuCCT1 cells.
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| Overall design |
3' UTR-Seq analyses for HUVEC-derived iLCCs (iLCC196-12, iLCC196-9, and iLCC195-10), HepG2s (HepG2-1 and HepG2-2), Huh6, Huh7, and HuCCT-1s (HuCCT1-1 and HuCCT1-2).
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| Contributor(s) |
Suzuki A, Ohkawa Y, Horisawa K, Goya T |
| Citation(s) |
35220676 |
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| Submission date |
Mar 16, 2021 |
| Last update date |
May 29, 2022 |
| Contact name |
Atsushi Suzuki |
| Organization name |
Medical Institute of Bioregulation, Kyushu University
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| Department |
Division of Organogenesis and Regeneration
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| Street address |
3-1-1 Maidashi, Higashi-ku
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| City |
Fukuoka |
| State/province |
Fukuoka |
| ZIP/Postal code |
812-8582 |
| Country |
Japan |
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| Platforms (1) |
| GPL18460 |
Illumina HiSeq 1500 (Homo sapiens) |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA714879 |
| SRA |
SRP310861 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE168997_UMI_count_matrix.csv.gz |
435.2 Kb |
(ftp)(http) |
CSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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