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Series GSE168997 Query DataSets for GSE168997
Status Public on Feb 27, 2022
Title Transcriptome analysis of human induced liver cancer-forming cells (iLCCs) , HepG2 cells, Huh6 cells, Huh7 cells, and HuCCT1 cells
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We found that a set of six transcription factors, FOXA3, HNF1A, HNF1B, LIN28B, L-MYC, and KLF5, can induce direct conversion of human umbilical vein endothelial cells (HUVECs) into liver cancer-forming cells (LCCs). These induced LCCs (iLCCs) efficiently arise tumors that closely resemble human combined hepatocellular cholangiocarcinoma after transplantation. We conducted 3' untranslated region (UTR)-seq (RNA-seq) analyses to investigate the characteristincs of iLCCs, HepG2 cells, Huh6 cells, Huh7 cells, and HuCCT1 cells.
Overall design 3' UTR-Seq analyses for HUVEC-derived iLCCs (iLCC196-12, iLCC196-9, and iLCC195-10), HepG2s (HepG2-1 and HepG2-2), Huh6, Huh7, and HuCCT-1s (HuCCT1-1 and HuCCT1-2).
Contributor(s) Suzuki A, Ohkawa Y, Horisawa K, Goya T
Citation(s) 35220676
Submission date Mar 16, 2021
Last update date May 29, 2022
Contact name Atsushi Suzuki
Organization name Medical Institute of Bioregulation, Kyushu University
Department Division of Organogenesis and Regeneration
Street address 3-1-1 Maidashi, Higashi-ku
City Fukuoka
State/province Fukuoka
ZIP/Postal code 812-8582
Country Japan
Platforms (1)
GPL18460 Illumina HiSeq 1500 (Homo sapiens)
Samples (9)
GSM5173750 iLCC196-12
GSM5173751 iLCC196-9
GSM5173752 iLCC195-10
BioProject PRJNA714879
SRA SRP310861

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Supplementary file Size Download File type/resource
GSE168997_UMI_count_matrix.csv.gz 435.2 Kb (ftp)(http) CSV
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Processed data are available on Series record

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