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Series GSE16160 Query DataSets for GSE16160
Status Public on May 19, 2009
Title Expression data of HL-60 leukemia cells after treatment with Curcumin and TCDD
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Curcumin has antileukemic potential that is mediated by dfifferent pathways. Because we could not confirm that the Arylhydrocarbonreceptor, a ligand activated transcription factor, is involved in curcumins antileukemic effects, we performed microarray experiments to have an overall screening of the pathways affected by curcumin in HL-60 cells.
We identified an involvement of the vitamin D receptor in the effects of curcumin on HL-60 cells by comparing our results with other experiments.
Overall design HL-60 cells were treated for 24h with 100 µM curcumin, 10 nM 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), or 0.5 % DMSO as control.
Contributor(s) Esser C, Goergens A, Frericks M
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Submission date May 19, 2009
Last update date Dec 06, 2018
Contact name Charlotte Esser
Phone 00492113389252
Organization name IUF
Department Immunologie
Street address Aufm Hennekamp 50
City Düsseldorf
State/province NRW
ZIP/Postal code 40225
Country Germany
Platforms (1)
GPL571 [HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Samples (6)
GSM405497 HL-60 + 100 µM curcumin, biological replicate 1
GSM405498 HL-60 + 100 µM curcumin, biological replicate 2
GSM405499 HL-60 + 10 nM TCDD, biological replicate 1
BioProject PRJNA117183

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE16160_GO-Proxy_of_regulated_genes.txt.gz 3.5 Kb (ftp)(http) TXT
GSE16160_GO-STATS_of_regulated_genes.txt.gz 21.8 Kb (ftp)(http) TXT
GSE16160_RAW.tar 9.7 Mb (http)(custom) TAR (of CEL)
GSE16160_RMA_normalized.txt.gz 1.1 Mb (ftp)(http) TXT
GSE16160_regulated_genes.txt.gz 32.0 Kb (ftp)(http) TXT
Processed data included within Sample table

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