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Series GSE16113 Query DataSets for GSE16113
Status Public on Jan 07, 2010
Title Activation of Host Wound Responses in Breast Cancer Microenvironment
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Cancer progression is mediated by processes that are also important in wound repair. As a result, cancers have been conceptualized as overhealing wounds or "wounds that do not heal," and gene expression signatures reflective of wound repair have shown value as predictors of breast cancer survival. Despite the widespread acknowledgment of commonalities between host responses to wounds and host responses to cancer, the gene expression responses of normal tissue adjacent to cancers have not been well characterized.
Overall design Using RNA extracted from histologically normal breast tissue from 105 patients, 121 arrays were performed, including 72 arrays representing 58 reduction mammoplasty patients and 49 arrays representing 47 cancer patients, we measured whole genome expression profiles and identified a gene expression signature that is induced in response to breast cancer.
Contributor(s) Troester MA
Citation(s) 19887484, 22002519
Submission date May 14, 2009
Last update date Feb 22, 2018
Contact name Melissa Troester
Organization name University of North Carolina at Chapel Hill
Department Epidemiology
Street address 135 Dauer Drive, CB 7435
City Chapel Hill
State/province NC
ZIP/Postal code 27599
Country USA
Platforms (5)
GPL4133 Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version)
GPL8264 UNC PerouLab 244K Custom Human Array version 3
GPL8265 UNC PerouLab 244K Custom Human Array version 4
Samples (121)
GSM402156 UNC06-0121A
GSM403057 UNC06-0678A
GSM403058 UNC06-0694A
BioProject PRJNA117229

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE16113_RAW.tar 6.9 Mb (http)(custom) TAR
Processed data included within Sample table

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