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| Status |
Public on Aug 18, 2020 |
| Title |
Associations between IFI44L gene variants and rates of respiratory tract infections during early childhood |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Background: Genetic heterogeneity in the innate immune system may account for variable susceptibility to respiratory tract infections (RTIs) in children. Objective: We aimed to assess the impact of polymorphisms rs273259 and rs1333969 in type I interferon related gene IFI44L on susceptibility to RTIs and acute otitis media in children. Methods: In two prospective, population-based birth cohorts, the FinnBrain Birth Cohort Study and the STEPS Study, IFI44L genotypes for rs273259 and rs1333969 were determined in relation to the development of RTIs until one and two years of age, respectively, and adjusted incidence rate ratios (aIRR) or odds ratios (OR) were calculated. At age 3 months, whole blood transcriptional profiles were analyzed and nasal samples were tested for respiratory viruses in a subset of children. Results: In respiratory virus-positive children at 3 months of age, IFI44L gene variants were associated with decreased expression levels of IFI44L and several other interferon related genes. Conclusions: Variant forms of IFI44L gene were protective against early-childhood RTIs or acute otitis media in two independent birth cohorts, and they attenuated interferon pathway activation by respiratory viruses.
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| Overall design |
71 samples, one each from 71 different subjects; no replicates; no controls; subjects at time of collection were afebrile and without symptoms of an RTI
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| Contributor(s) |
Lempainen J, Korhonen LS, Kantojärvi K, Heinonen S, Toivonen L, Räty P, Ramilo O, Mejias A, Laine A, Vuorinen T, Waris M, Karlsson L, Karlsson H, Paunio T, Peltola V |
| Citation(s) |
32561935 |
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| Submission date |
May 08, 2020 |
| Last update date |
Mar 16, 2023 |
| Contact name |
Nicole Baldwin |
| E-mail(s) |
Nicole.Baldwin@BSWHealth.org
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| Organization name |
Baylor Research Institute
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| Street address |
3434 Live Oak St
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| City |
Dallas |
| ZIP/Postal code |
75204 |
| Country |
USA |
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| Platforms (1) |
| GPL13369 |
Illumina Human Whole-Genome DASL HT |
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| Samples (71)
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| Relations |
| BioProject |
PRJNA631239 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE150133_non-normalized.txt.gz |
17.0 Mb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
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