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| Status |
Public on Feb 28, 2021 |
| Title |
Expression data from Inflammatory breast cancer (IBC) cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
ERβ expression is associated with less metastasis in patients with IBC tumors. We investigated this association in preclinical models of IBC by knocking out ERβ in cells. Ablation of ERβ promotes migration and invasion of IBC cells and increases the metastatic potential of IBC tumors in vivo.
We used microarrays to detail the global programme of gene expression underlying the increased migration of ERβ knockout cells and identified distinct classes of up-regulated genes during this process.
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| Overall design |
Inflammatory breast cancer KPL4 cells with CRISPR/CAS9-mediated knockout of ERβ were used for RNA extraction and hybridization on Affymetrix microarrays
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| |
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| Contributor(s) |
Christoforos T |
| Citation(s) |
33514514 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| R01 CA237200 |
Exploring the role of estrogen receptor beta in progression and metastasis of Inflammatory breast cancer |
UNIVERSITY OF PENNSYLVANIA |
Christoforos Thomas |
|
| Submission date |
May 04, 2020 |
| Last update date |
May 31, 2021 |
| Contact name |
Christoforos Thomas |
| E-mail(s) |
thomaschristoforos@gmail.com
|
| Organization name |
University of Pennsylvania
|
| Street address |
3400 Civic Center Blvd
|
| City |
Philadelphia |
| State/province |
Pennsylvania |
| ZIP/Postal code |
19104 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL23126 |
[Clariom_D_Human] Affymetrix Human Clariom D Assay [transcript (gene) version] |
|
| Samples (6)
|
| GSM4514248 |
KPL4 cells, ERβ Knockout, biological rep 1 |
| GSM4514249 |
KPL4 cells, ERβ Knockout, biological rep 2 |
| GSM4514250 |
KPL4 cells, ERβ Knockout, biological rep 3 |
|
| Relations |
| BioProject |
PRJNA630271 |
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