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Series GSE145340 Query DataSets for GSE145340
Status Public on Feb 15, 2020
Title 19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis (Agilent-022060)
Organism Homo sapiens
Experiment type Genome variation profiling by array
Summary Genomic aberrations of neuroblastoma occurring in late childhood and adolescence are uncommon and still underestimated.
Public DNA copy number profiles of 556 tumors (discovery set) and of 208 tumors obtained by array-CGH assay (validation set) were used to verify if 19p loss is significantly over-represented in children and adolescents. The 19p loss occurrence was separately tested within different age groups in the discovery and validation set and the resulting P values were combined and corrected by Bonferroni’s method.
In both sets, the lowest age group significantly associated with 19p loss (discovery set: 20%; validation set: 35%) was 6 years. The 19p loss was considered to be a significant marker for overall survival in patients over 6 years of age. Relevant tumor suppressor genes (KEAP1, DNM2, SMARCA4, SLC44A2 and CDKN2D) and microRNAs (miR-181c, miR-27a, and mirR-199a-1) were in 19p loss. Down-regulation of DNM2, SLC44A2 and CDKN2D associated with poor patient outcome and older age. Among the recurrent NB chromosomal aberrations, only 1q gain was enriched in patients older than 6 years and was mutually exclusive respect to 19p loss.
Our data demonstrate that 19p loss is a genomic biomarker of NBs diagnosed in older children that can predict clinical outcome.
 
Overall design This study includes 208 neuroblastoma tumors obtained by array-CGH assay were used to verify if 19p loss is significantly over-represented in children and adolescents.
This subseries includes 24 neuroblastoma tumors analyzed on Agilent-022060.
 
Contributor(s) Pezzolo A
Citation(s) 32337068
Submission date Feb 14, 2020
Last update date May 19, 2020
Contact name Annalisa Pezzolo
E-mail(s) annalisapezzolo@gaslini.org
Organization name IRCCS Istituto Gaslini
Lab Laboratorio Cellule Staminali e Terapie Cellulari
Street address Via Gerolamo Gaslini, 3
City Genova
ZIP/Postal code 16147
Country Italy
 
Platforms (1)
GPL10123 Agilent-022060 SurePrint G3 Human CGH Microarray 4x180K (Feature Number version)
Samples (24)
GSM4315185 neuroblastoma sample 43
GSM4315186 neuroblastoma sample 44
GSM4315187 neuroblastoma sample 45
This SubSeries is part of SuperSeries:
GSE145341 19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis
Relations
BioProject PRJNA606782

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE145340_RAW.tar 471.9 Mb (http)(custom) TAR (of TXT)
GSE145340_data_matrix_GPL10123.txt.gz 26.0 Mb (ftp)(http) TXT
Processed data included within Sample table
Processed data are available on Series record

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