|
| Status |
Public on Apr 28, 2009 |
| Title |
miR101 overexpression vs. EZH2 RNAi |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Transcriptional analysis of genes in SKBr3 cells.
Enhancer of zeste homolog 2 (EZH2) is a mammalian histone methyltransferase that contributes to the epigenetic silencing of target genes and regulates the survival and metastasis of cancer cells. EZH2 is overexpressed in aggressive solid tumors by mechanisms that remain unclear. Here we show that the expression and function of EZH2 in cancer cell lines are inhibited by microRNA-101 (miR-101).
|
| |
|
| Overall design |
Two-condition experiment: miR101 overexpression vs. EZH2 RNAi in SKBr3 breast cancer cells.
|
| |
|
| Contributor(s) |
Maher CA |
| Citation(s) |
19008416 |
| |
| Submission date |
Oct 20, 2008 |
| Last update date |
Feb 22, 2018 |
| Contact name |
Christopher Maher |
| E-mail(s) |
chrmaher@med.umich.edu
|
| Phone |
734-764-3336
|
| Organization name |
Michigan Center for Translational Pathology
|
| Street address |
1500 E. Medical Center Drive
|
| City |
Ann Arbor |
| State/province |
MI |
| ZIP/Postal code |
48105 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL4133 |
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version) |
|
| Samples (4)
|
|
| Relations |
| BioProject |
PRJNA109607 |
Less...
More...