|
| Status |
Public on Jul 20, 2020 |
| Title |
Transcriptomic alterations of stromal cells during ageing |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The hematopoietic microenviroment plays a pivotal role in erythropoiesis. Here we compare the transcriptome profiles of the bone marrow niche. in young and aged mice
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| |
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| Overall design |
Examine the gene expression profile of different stromal populations in the bone marrow for young (8-12 weeks) and aged (24-25 months) mice by bulk RNA-seq (100 cells)
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| |
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| Contributor(s) |
Valletta S, Thomas A, Nerlov C |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
May 08, 2019 |
| Last update date |
Jul 20, 2020 |
| Contact name |
Claus Nerlov |
| E-mail(s) |
claus.nerlov@imm.ox.ac.uk
|
| Organization name |
Weatheral Institute of Molecular Medicine
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| Department |
MRC Molecular Haematology Unit
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| Lab |
Nerlov Laboratory
|
| Street address |
John Radcliffe Hospital, University of Oxford
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| City |
Oxford |
| ZIP/Postal code |
OX3 9DS |
| Country |
United Kingdom |
| |
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| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
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| Samples (36)
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| This SubSeries is part of SuperSeries: |
| GSE130899 |
Using bone marrow stromal cells as micro-environmental sensors identifies IL-6 and TGFa signalling as regulators of declining erythropoiesis and lymphopoiesis during hematopoietic ageing |
|
| Relations |
| BioProject |
PRJNA541905 |
| SRA |
SRP197076 |
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