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| Status |
Public on Dec 27, 2018 |
| Title |
Acne flare-up in treatment process: investigating the difference of gene expression in peripheral blood |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Objectives: To identify gene expression changes in acne flare-up patients, thereby exploring the mechanisms of acne flare-up after treatment.
Methods: 11 acne patients and 3 healthy people were divided into 4 groups (group1: 4 with flare-up, group2: 4 with improvement, group3: 3 without obvious changes, group4: healthy control). Peripheral blood of patients before and after isotretinoin or minocycline were collected. RNA-seq were used to detect the gene expression. We applied data in self-contrast and intergroup comparisons.
Results: In the self-contrast of group1, 22 upregulated genes were involved in Toll-like receptor signaling pathway and inflammatory response. Comparing group1 and group3 before treatment, 1778 upregulated genes enriched in Th17 cell differentiation, while 57 downregulated genes enriched in defensive response to organism.
Conclusions: The gene expression profiles of acne flare-up patients changed. Inflammatory, immune responses played a prominent role in acne flare-up process and relatively weak defensive response to microbes, comedogenesis might be risk factors.
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| Overall design |
RNA-seq were used to detect the gene expressions in acne flare-up patients and healthy controls.
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| Contributor(s) |
Jiang Y |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Dec 26, 2018 |
| Last update date |
Mar 21, 2019 |
| Contact name |
Yuchen Jiang |
| E-mail(s) |
197473463@qq.com
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| Organization name |
Third Affiliated Hospital of Sun Yat-sen University
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| Street address |
600 Tianhe Road
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| City |
Guangzhou |
| State/province |
Guangdong |
| ZIP/Postal code |
510630 |
| Country |
China |
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| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
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| Samples (25)
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| GSM3530930 |
Group1, before treatment, rep4 |
| GSM3530931 |
Group1, after treatment, rep1 |
| GSM3530932 |
Group1, after treatment, rep2 |
| GSM3530933 |
Group1, after treatment, rep3 |
| GSM3530934 |
Group1, after treatment, rep4 |
| GSM3530935 |
Group2, before treatment, rep1 |
| GSM3530936 |
Group2, before treatment, rep2 |
| GSM3530937 |
Group2, before treatment, rep3 |
| GSM3530938 |
Group2, before treatment, rep4 |
| GSM3530939 |
Group2, after treatment, rep1 |
| GSM3530940 |
Group2, after treatment, rep2 |
| GSM3530941 |
Group2, after treatment, rep3 |
| GSM3530942 |
Group2, after treatment, rep4 |
| GSM3530943 |
Group3, before treatment, rep1 |
| GSM3530944 |
Group3, before treatment, rep2 |
| GSM3530945 |
Group3, before treatment, rep3 |
| GSM3530946 |
Group3, after treatment, rep1 |
| GSM3530947 |
Group3, after treatment, rep2 |
| GSM3530948 |
Group3, after treatment, rep3 |
| GSM3530949 |
Group4, rep1 |
| GSM3530950 |
Group4, rep2 |
| GSM3530951 |
Group4, rep3 |
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| Relations |
| BioProject |
PRJNA511891 |
| SRA |
SRP174497 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE124389_Differentially_Expressed_Genes.xlsx |
4.8 Mb |
(ftp)(http) |
XLSX |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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