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| Status |
Public on Apr 07, 2021 |
| Title |
Cardamonin repel colitis and its associated colorectal cancer |
| Platform organism |
synthetic construct |
| Sample organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
The effect of Cardamonin was checked on Dextran sulfate sodium and Azoxymethane (AOM) induced colon cancer in C57Bl/6 mice.
C57Bl/6 were given a single AOM (10mg/kg B.wt) intraperitonielly at day 0 and three bouts of 5% DSS at days 5-10, 25-30, 45-50. At day 140, the mice were sacrificed and colon was monitored for tumors. Cardamonin treatment (10mg/Kg B.wt, p.o) was started simulatenously for one group. For the second group it was started after 16 of first AOM injection. The study was terminated at 140 day. The RNA was ioslated uisng mirVANA kit from each samples followed miRNA analysis uisng affymetrix gene chip miRNA array 4.0
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| Overall design |
16 samples were analysed. The differential expression of miRNAs between groups were analysed.
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| Contributor(s) |
James S, Aparna JS, Paul AS, Manendra BL, Sabira M, Girijadevi R, Harikumar KB |
| Citation(s) |
33947113 |
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| Submission date |
Oct 22, 2018 |
| Last update date |
Jun 03, 2021 |
| Contact name |
Dr. Harikumar K B |
| E-mail(s) |
harikumar@rgcb.res.in
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| Phone |
+91-471-2529-596
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| Organization name |
Rajiv Gandhi centre for Biotechnology
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| Department |
Cancer Research Program
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| Lab |
CRP-7
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| Street address |
Poojappura
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| City |
Thycaud |
| State/province |
Kerala |
| ZIP/Postal code |
695 014 |
| Country |
India |
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| Platforms (1) |
| GPL19117 |
[miRNA-4] Affymetrix Multispecies miRNA-4 Array |
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| Samples (16)
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| GSM3440003 |
C4: Healthy colon, biological rep.4 |
| GSM3440004 |
C5: Healthy colon, biological rep.5 |
| GSM3440005 |
C6: Healthy colon, biological rep.6 |
| GSM3440006 |
G1-1: Colon, AOM+DSS treated, Vehicle control, biological rep.1 |
| GSM3440007 |
G1-3: Colon, AOM+DSS treated, Vehicle control, biological rep.2 |
| GSM3440008 |
G1-5: Colon, AOM+DSS treated, Vehicle control, biological rep.3 |
| GSM3440009 |
G1-9: Colon, AOM+DSS treated, Vehicle control, biological rep.4 |
| GSM3440010 |
G2-2: Colon, AOM+DSS treated, Cardamonin simultaneous treatment, biol.rep.1 |
| GSM3440011 |
G2-5: Colon, AOM+DSS treated, Cardamonin simultaneous treatment, biol.rep.2 |
| GSM3440012 |
G2-9: Colon, AOM+DSS treated, Cardamonin simultaneous treatment, biol.rep.3 |
| GSM3440013 |
G3-3: Colon, AOM+DSS treated, Cardamonin treatment after 16 week, biol.rep.1 |
| GSM3440014 |
G3_4: Colon, AOM+DSS treated, Cardamonin treatment after 16 week, biol.rep.2 |
| GSM3440015 |
G3_5: Colon, AOM+DSS treated, Cardamonin treatment after 16 week, biol.rep.3 |
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| Relations |
| BioProject |
PRJNA497866 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE121608_RAW.tar |
11.6 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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