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Series GSE121608 Query DataSets for GSE121608
Status Public on Apr 07, 2021
Title Cardamonin repel colitis and its associated colorectal cancer
Platform organism synthetic construct
Sample organism Mus musculus
Experiment type Expression profiling by array
Summary The effect of Cardamonin was checked on Dextran sulfate sodium and Azoxymethane (AOM) induced colon cancer in C57Bl/6 mice.
C57Bl/6 were given a single AOM (10mg/kg B.wt) intraperitonielly at day 0 and three bouts of 5% DSS at days 5-10, 25-30, 45-50. At day 140, the mice were sacrificed and colon was monitored for tumors. Cardamonin treatment (10mg/Kg B.wt, p.o) was started simulatenously for one group. For the second group it was started after 16 of first AOM injection. The study was terminated at 140 day. The RNA was ioslated uisng mirVANA kit from each samples followed miRNA analysis uisng affymetrix gene chip miRNA array 4.0
Overall design 16 samples were analysed. The differential expression of miRNAs between groups were analysed.
Contributor(s) James S, Aparna JS, Paul AS, Manendra BL, Sabira M, Girijadevi R, Harikumar KB
Citation(s) 33947113
Submission date Oct 22, 2018
Last update date Jun 03, 2021
Contact name Dr. Harikumar K B
Phone +91-471-2529-596
Organization name Rajiv Gandhi centre for Biotechnology
Department Cancer Research Program
Lab CRP-7
Street address Poojappura
City Thycaud
State/province Kerala
ZIP/Postal code 695 014
Country India
Platforms (1)
GPL19117 [miRNA-4] Affymetrix Multispecies miRNA-4 Array
Samples (16)
GSM3440000 C1: Healthy colon, biological rep.1
GSM3440001 C2: Healthy colon, biological rep.2
GSM3440002 C3: Healthy colon, biological rep.3
BioProject PRJNA497866

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Supplementary file Size Download File type/resource
GSE121608_RAW.tar 11.6 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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