|
| Status |
Public on Aug 02, 2018 |
| Title |
Co-evolution of Met amplification and Hgf overexpression mediate resistance to BRAF inactivation in mouse anaplastic thyroid cancers. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Affymetric arrays were performed on thyroid samples collected from GEMMs: normal thyroid, TPO-Cre/LSL-Braf (PTC), TPO-Cre/tetO-BRAF/LSL-rtTAiresGFP/p53-flox (ATC) and TPO-Cre/tetO-BRAF/LSL-rtTAiresGFP/p53-flox (recurrent tumors)
As above
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| |
|
| Overall design |
Thyroids and tumor-bearing thyroid glands were isolated from various mouse models at baseline
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| |
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| Contributor(s) |
Knauf J, Fagin J |
| Citation(s) |
29990309 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| P50 CA172012 |
SPORE in Thyroid Cancer |
Sloan Kettering Institute for Cancer Research |
JAMES A FAGIN |
| R01 CA050706 |
Molecular Pathophysiology of Thyroid Cell Growth |
Sloan Kettering Institute for Cancer Research |
JAMES A FAGIN |
| R01 CA072597 |
Oncogenic Events in Thyroid Neoplasia |
Sloan Kettering Institute for Cancer Research |
JAMES A FAGIN |
| P30 CA008748 |
Cancer Center Support Grant |
Sloan Kettering Institute for Cancer Research |
CRAIG B THOMPSON |
|
| |
| Submission date |
Aug 01, 2018 |
| Last update date |
Nov 01, 2018 |
| Contact name |
Jeffrey A Knauf |
| E-mail(s) |
Knaufj@mskcc.org
|
| Phone |
646-888-2164
|
| Organization name |
Memorial Sloan Kettering Cancer Center
|
| Department |
HOPP
|
| Street address |
1275 York Ave
|
| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10065 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL8321 |
[Mouse430A_2] Affymetrix Mouse Genome 430A 2.0 Array |
|
| Samples (24)
|
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| Relations |
| BioProject |
PRJNA484021 |
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