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| Status |
Public on Jun 16, 2020 |
| Title |
a New Marine-Derived Asterosaponin (CN-3) alleviated the proliferation of U251 MG cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Analysis of U251 glioblastoma multiforme (GBM) cells treated with a new culcita novaeguineae asterosaponion, CN-3. A new asterosaponin was isolated from culcita novaeguineae, an abundant marine resource in the south China sea. The asterosaponin induced significant growth inhibition with a 50% inhibitory concentration at 48 h of 2.013 μg/mL in U251MG cells. 1.8μg/mL of the asterosaponin reduced U251 MG cells viability from 100 % to 42.5% (24 h), 37.4% (48 h) and 52.1% (72 h). In this study, a microarray analysis was performed using RNA prepared from U251MG GBM cells treated with the asterosaponion. These data revealed that 661 genes had significant differential expressions.
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| Overall design |
U251 cells were treated with asterosaponin or control, At 48h, total RNA were extracted for microarray experiment. Four replicates were performed of asterosaponion, and two replicates were performed of control.
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| Contributor(s) |
Qiu P, Lu Y, Tang H |
| Citation(s) |
32764572 |
| |
| Submission date |
Dec 20, 2017 |
| Last update date |
Nov 11, 2020 |
| Contact name |
Peng-Cheng Qiu |
| E-mail(s) |
qpc023@126.com
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| Phone |
86-13772051376
|
| Organization name |
Fourth Military Medical University
|
| Street address |
Changle West Road 169
|
| City |
Xi'an |
| ZIP/Postal code |
710032 |
| Country |
China |
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| Platforms (1) |
| GPL15207 |
[PrimeView] Affymetrix Human Gene Expression Array |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA423237 |
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