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Series GSE100858 Query DataSets for GSE100858
Status Public on Aug 10, 2017
Title IL-22 inhibits allergic airway inflammation in house dust mite-induced asthma models
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary While the pathogenesis of asthma is mainly orchestrated by antigen-specific Th2 cells and their cytokines, recent findings indicate the involvement of other subsets of helper T cells including Th17 cells. Previous studies have shown that IL-22, one of Th17 cell-related cytokines, plays multiple roles in regulating allergic airway inflammation; however, the mechanism underlying the Il-22-mediated regulation remains unclear. Here, we show that allergic airway inflammation upon intratracheal administration of house dust mite extract (HDM), a representative allergen, were exacerbated in IL-22-deficient mice. To address the molecular mechanisms by which IL-22 inhibits the development of HDM-induced allergic airway inflammation, we next performed an unbiased comprehensive screening of genes induced by IL-22 administration in the lung by RNA-seq analysis.
Overall design Lung total RNA profiles of wild type (WT) and IL-22 knock out mice were generated by deep sequencing, using Illumina Hiseq.
Contributor(s) Ito T, Hirose K, Nakajima H
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Submission date Jul 06, 2017
Last update date May 15, 2019
Contact name Takashi Ito
Organization name Chiba university
Street address Inohana
City Chiba
State/province Chiba
ZIP/Postal code 260-8670
Country Japan
Platforms (1)
GPL18480 Illumina HiSeq 1500 (Mus musculus)
Samples (4)
GSM2695307 WT_asthma
GSM2695308 IL22KO_asthma
GSM2695309 PBS_Lung
BioProject PRJNA393301
SRA SRP111182

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE100858_Lung_processed.txt.gz 355.4 Kb (ftp)(http) TXT
GSE100858_asthma_processed.txt.gz 356.4 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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