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    CHD1L chromodomain helicase DNA binding protein 1 like [ Homo sapiens (human) ]

    Gene ID: 9557, updated on 3-Nov-2024

    Summary

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    Official Symbol
    CHD1Lprovided by HGNC
    Official Full Name
    chromodomain helicase DNA binding protein 1 likeprovided by HGNC
    Primary source
    HGNC:HGNC:1916
    See related
    Ensembl:ENSG00000131778 MIM:613039; AllianceGenome:HGNC:1916
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ALC1; CHDL
    Summary
    This gene encodes a DNA helicase protein involved in DNA repair. The protein converts ATP to add poly(ADP-ribose) as it regulates chromatin relaxation following DNA damage. Overexpression of this gene has been linked to several types of cancers. [provided by RefSeq, Feb 2017]
    Expression
    Ubiquitous expression in testis (RPKM 13.4), bone marrow (RPKM 10.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CHD1L in Genome Data Viewer
    Location:
    1q21.1
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (147172747..147295762)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (147512572..147635662, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (146644326..146767443)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NBPF member 13, pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:146633127-146634326 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1277 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1278 Neighboring gene protein kinase AMP-activated non-catalytic subunit beta 2 Neighboring gene protein disulfide isomerase family A member 3 pseudogene 1 Neighboring gene flavin containing dimethylaniline monoxygenase 5 Neighboring gene chaperonin containing TCP1 subunit 8 pseudogene 1 Neighboring gene HNF4 motif-containing MPRA enhancer 9 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1279 Neighboring gene ribosomal protein L7a pseudogene 15 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:146764440-146765639 Neighboring gene prostaglandin reductase 1 pseudogene Neighboring gene MPRA-validated peak402 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:146807941-146808527 Neighboring gene long intergenic non-protein coding RNA 624 Neighboring gene olfactory receptor family 13 subfamily Z member 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cell adhesion induces overexpression of chromodomain helicase/ATPase DNA binding protein 1-like gene (CHD1L) and contributes to cell adhesion-mediated drug resistance (CAM-DR) in multiple myeloma cells. Xu X, et al. Leuk Res, 2016 Aug. PMID 27258734
    2. First-in-Class Inhibitors of Oncogenic CHD1L with Preclinical Activity against Colorectal Cancer. Abbott JM, et al. Mol Cancer Ther, 2020 Aug. PMID 32499299, Free PMC Article
    3. CHD1L is associated with poor survival and promotes the proliferation and metastasis of intrahepatic cholangiocarcinoma. Li S, et al. Oncol Rep, 2019 Aug. PMID 31173252, Free PMC Article
    4. Mechanistic Insights into Regulation of the ALC1 Remodeler by the Nucleosome Acidic Patch. Lehmann LC, et al. Cell Rep, 2020 Dec 22. PMID 33357431, Free PMC Article
    5. ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination-deficient cells. Verma P, et al. Nat Cell Biol, 2021 Feb. PMID 33462394, Free PMC Article

    See all (107) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification and functional characteristics of CHD1L gene variants implicated in human Mullerian duct anomalies.
      Title: Identification and functional characteristics of CHD1L gene variants implicated in human Müllerian duct anomalies.
    2. Host genetic variation at a locus near CHD1L impacts HIV sequence diversity in a South African population.
      Title: Host genetic variation at a locus near CHD1L impacts HIV sequence diversity in a South African population.
    3. The chromatin remodeler ALC1 underlies resistance to PARP inhibitor treatment.
      Title: The chromatin remodeler ALC1 underlies resistance to PARP inhibitor treatment.
    4. Chromodomain Helicase DNA Binding Protein 1-like, a negative regulator of Forkhead box O3a, promotes the proliferation and migration of Angiotensin II-induced vascular smooth muscle cells.
      Title: Chromodomain Helicase DNA Binding Protein 1-like, a negative regulator of Forkhead box O3a, promotes the proliferation and migration of Angiotensin II-induced vascular smooth muscle cells.
    5. Genome-wide scanning for CHD1L gene in papillary thyroid carcinoma complicated with type 2 diabetes mellitus.
      Title: Genome-wide scanning for CHD1L gene in papillary thyroid carcinoma complicated with type 2 diabetes mellitus.
    6. CHD1L prevents lipopolysaccharide-induced hepatocellular carcinomar cell death by activating hnRNP A2/B1-nmMYLK axis.
      Title: CHD1L prevents lipopolysaccharide-induced hepatocellular carcinomar cell death by activating hnRNP A2/B1-nmMYLK axis.
    7. CHD1L augments autophagy-mediated migration of hepatocellular carcinoma through targeting ZKSCAN3.
      Title: CHD1L augments autophagy-mediated migration of hepatocellular carcinoma through targeting ZKSCAN3.
    8. Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling.
      Title: Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling.
    9. Multiple roles for PARP1 in ALC1-dependent nucleosome remodeling.
      Title: Multiple roles for PARP1 in ALC1-dependent nucleosome remodeling.
    10. Mechanistic Insights into Regulation of the ALC1 Remodeler by the Nucleosome Acidic Patch.
      Title: Mechanistic Insights into Regulation of the ALC1 Remodeler by the Nucleosome Acidic Patch.
    Submit: New GeneRIF Correction See all GeneRIFs (51)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated 2018-08-30)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated 2018-08-30)

    ClinGen Genome Curation Page

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies protein quantitative trait loci (pQTLs).
    EBI GWAS Catalog
    A genome-wide association study in the genetic analysis of idiopathic thrombophilia project suggests sex-specific regulation of mitochondrial DNA levels.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ22530

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ATP-dependent chromatin remodeler activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA helicase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables histone reader activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables poly-ADP-D-ribose modification-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA damage response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA repair TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in site of DNA damage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chromodomain-helicase-DNA-binding protein 1-like
    Names
    amplified in liver cancer 1
    amplified in liver cancer protein 1
    NP_001243265.1
    NP_001243266.1
    NP_001243267.1
    NP_001335380.1
    NP_001335381.1
    NP_001335382.1
    NP_001335383.1
    NP_001335384.1
    NP_001335385.1
    NP_001335386.1
    NP_001335387.1
    NP_001335388.1
    NP_001335389.1
    NP_001335390.1
    NP_001335391.1
    NP_001335392.1
    NP_001335393.1
    NP_001335394.1
    NP_001335395.1
    NP_004275.4
    NP_078844.2
    XP_024306819.1
    XP_047290957.1
    XP_054195684.1
    XP_054195685.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052905.1 RefSeqGene

      Range
      74491..127569
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001256336.3 → NP_001243265.1  chromodomain-helicase-DNA-binding protein 1-like isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region which results in translation from a downstream start codon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AC242426
      UniProtKB/TrEMBL
      X5D2E5
      Conserved Domains (5) summary
      PLN03142
      Location:16 → 599
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      cd00046
      Location:15 → 105
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd03331
      Location:616 → 766
      Macro_Poa1p_like_SNF2; Macro domain, Poa1p_like family, SNF2 subfamily. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ...
      pfam00271
      Location:246 → 359
      Helicase_C; Helicase conserved C-terminal domain
      pfam06936
      Location:546 → 595
      Selenoprotein_S; Selenoprotein S (SelS)

    2. NM_001256337.3 → NP_001243266.1  chromodomain-helicase-DNA-binding protein 1-like isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks several exons in the 5' coding region which results in translation from a downstream start codon, compared to variant 1. The resulting protein (isoform 4) is shorter when it is compared to isoform 1. Variants 4 and 12-22 all encode the same isoform (4).
      Source sequence(s)
      AC242426
      UniProtKB/TrEMBL
      B4DLS6
      Conserved Domains (2) summary
      PLN03142
      Location:1 → 418
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      cd03331
      Location:435 → 585
      Macro_Poa1p-like_SNF2; macrodomain, Poa1p-like family, SNF2 subfamily

    3. NM_001256338.3 → NP_001243267.1  chromodomain-helicase-DNA-binding protein 1-like isoform 5

      See identical proteins and their annotated locations for NP_001243267.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks several exons in the 5' coding region which results in translation from a downstream start codon, compared to variant 1. The resulting protein (isoform 5) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AC242426
      Consensus CDS
      CCDS58021.1
      UniProtKB/TrEMBL
      B4DLS6
      Related
      ENSP00000358263.3, ENST00000369259.4
      Conserved Domains (2) summary
      cd03331
      Location:512 → 662
      Macro_Poa1p_like_SNF2; Macro domain, Poa1p_like family, SNF2 subfamily. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ...
      cl26465
      Location:44 → 495
      SNF2_N; SNF2 family N-terminal domain

    4. NM_001348451.2 → NP_001335380.1  chromodomain-helicase-DNA-binding protein 1-like isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variant 8, encodes isoform 6.
      Source sequence(s)
      AC241584, AC242426
      Consensus CDS
      CCDS91038.1
      UniProtKB/TrEMBL
      A0A0A0MSH9, X5D2E5
      Conserved Domains (2) summary
      cd03331
      Location:644 → 794
      Macro_Poa1p_like_SNF2; Macro domain, Poa1p_like family, SNF2 subfamily. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ...
      cl26465
      Location:1 → 627
      SNF2_N; SNF2 family N-terminal domain

    5. NM_001348452.2 → NP_001335381.1  chromodomain-helicase-DNA-binding protein 1-like isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), as well as variant 7, encodes isoform 6.
      Source sequence(s)
      AC242426
      Consensus CDS
      CCDS91038.1
      UniProtKB/TrEMBL
      A0A0A0MSH9, X5D2E5
      Related
      ENSP00000389031.3, ENST00000431239.6
      Conserved Domains (2) summary
      cd03331
      Location:644 → 794
      Macro_Poa1p_like_SNF2; Macro domain, Poa1p_like family, SNF2 subfamily. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ...
      cl26465
      Location:1 → 627
      SNF2_N; SNF2 family N-terminal domain

    6. NM_001348453.2 → NP_001335382.1  chromodomain-helicase-DNA-binding protein 1-like isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC242426
      UniProtKB/TrEMBL
      X5D2E5
      Conserved Domains (2) summary
      cd03331
      Location:603 → 753
      Macro_Poa1p_like_SNF2; Macro domain, Poa1p_like family, SNF2 subfamily. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ...
      cl26465
      Location:2 → 586
      SNF2_N; SNF2 family N-terminal domain

    7. NM_001348454.2 → NP_001335383.1  chromodomain-helicase-DNA-binding protein 1-like isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC242426
      Consensus CDS
      CCDS91037.1
      UniProtKB/TrEMBL
      A0A0A0MRH8, B4DLS6
      Related
      ENSP00000355100.6, ENST00000361293.10
      Conserved Domains (2) summary
      cd03331
      Location:564 → 714
      Macro_Poa1p_like_SNF2; Macro domain, Poa1p_like family, SNF2 subfamily. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ...
      cl26465
      Location:45 → 547
      SNF2_N; SNF2 family N-terminal domain

    8. NM_001348455.2 → NP_001335384.1  chromodomain-helicase-DNA-binding protein 1-like isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC242426
      UniProtKB/TrEMBL
      B4DLS6
      Conserved Domains (2) summary
      cd03331
      Location:553 → 703
      Macro_Poa1p_like_SNF2; Macro domain, Poa1p_like family, SNF2 subfamily. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ...
      cl26465
      Location:2 → 536
      SNF2_N; SNF2 family N-terminal domain

    9. NM_001348456.2 → NP_001335385.1  chromodomain-helicase-DNA-binding protein 1-like isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variants 4 and 13-22, encodes isoform 4.
      Source sequence(s)
      AC242426
      UniProtKB/TrEMBL
      B4DLS6
      Conserved Domains (2) summary
      PLN03142
      Location:1 → 418
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      cd03331
      Location:435 → 585
      Macro_Poa1p-like_SNF2; macrodomain, Poa1p-like family, SNF2 subfamily

    10. NM_001348457.2 → NP_001335386.1  chromodomain-helicase-DNA-binding protein 1-like isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variants 4, 12, and 14-22, encodes isoform 4.
      Source sequence(s)
      AC242426
      UniProtKB/TrEMBL
      B4DLS6
      Conserved Domains (2) summary
      PLN03142
      Location:1 → 418
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      cd03331
      Location:435 → 585
      Macro_Poa1p-like_SNF2; macrodomain, Poa1p-like family, SNF2 subfamily

    11. NM_001348458.2 → NP_001335387.1  chromodomain-helicase-DNA-binding protein 1-like isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variants 4, 12-13, and 15-22, encodes isoform 4.
      Source sequence(s)
      AC242426
      UniProtKB/TrEMBL
      B4DLS6
      Conserved Domains (2) summary
      PLN03142
      Location:1 → 418
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      cd03331
      Location:435 → 585
      Macro_Poa1p-like_SNF2; macrodomain, Poa1p-like family, SNF2 subfamily

    12. NM_001348459.2 → NP_001335388.1  chromodomain-helicase-DNA-binding protein 1-like isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), as well as variants 4, 12-14, and 16-22, encodes isoform 4.
      Source sequence(s)
      AC242426
      UniProtKB/TrEMBL
      B4DLS6
      Conserved Domains (2) summary
      PLN03142
      Location:1 → 418
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      cd03331
      Location:435 → 585
      Macro_Poa1p-like_SNF2; macrodomain, Poa1p-like family, SNF2 subfamily

    13. NM_001348460.2 → NP_001335389.1  chromodomain-helicase-DNA-binding protein 1-like isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variants 4, 12-15, and 17-22, encodes isoform 4.
      Source sequence(s)
      AC242426
      UniProtKB/TrEMBL
      B4DLS6
      Conserved Domains (2) summary
      PLN03142
      Location:1 → 418
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      cd03331
      Location:435 → 585
      Macro_Poa1p-like_SNF2; macrodomain, Poa1p-like family, SNF2 subfamily

    14. NM_001348461.2 → NP_001335390.1  chromodomain-helicase-DNA-binding protein 1-like isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), as well as variants 4, 12-16, and 18-22, encodes isoform 4.
      Source sequence(s)
      AC242426
      UniProtKB/TrEMBL
      B4DLS6
      Conserved Domains (2) summary
      PLN03142
      Location:1 → 418
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      cd03331
      Location:435 → 585
      Macro_Poa1p-like_SNF2; macrodomain, Poa1p-like family, SNF2 subfamily

    15. NM_001348462.2 → NP_001335391.1  chromodomain-helicase-DNA-binding protein 1-like isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18), as well as variants 4, 12-17, and 19-22, encodes isoform 4.
      Source sequence(s)
      AC242426
      UniProtKB/TrEMBL
      B4DLS6
      Conserved Domains (2) summary
      PLN03142
      Location:1 → 418
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      cd03331
      Location:435 → 585
      Macro_Poa1p-like_SNF2; macrodomain, Poa1p-like family, SNF2 subfamily

    16. NM_001348463.2 → NP_001335392.1  chromodomain-helicase-DNA-binding protein 1-like isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19), as well as variants 4, 12-18, and 20-22, encodes isoform 4.
      Source sequence(s)
      AC242426
      UniProtKB/TrEMBL
      B4DLS6
      Conserved Domains (2) summary
      PLN03142
      Location:1 → 418
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      cd03331
      Location:435 → 585
      Macro_Poa1p-like_SNF2; macrodomain, Poa1p-like family, SNF2 subfamily

    17. NM_001348464.2 → NP_001335393.1  chromodomain-helicase-DNA-binding protein 1-like isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20), as well as variants 4, 12-19 and 21-22, encodes isoform 4.
      Source sequence(s)
      AC242426
      UniProtKB/TrEMBL
      B4DLS6
      Conserved Domains (2) summary
      PLN03142
      Location:1 → 418
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      cd03331
      Location:435 → 585
      Macro_Poa1p-like_SNF2; macrodomain, Poa1p-like family, SNF2 subfamily

    18. NM_001348465.2 → NP_001335394.1  chromodomain-helicase-DNA-binding protein 1-like isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21), as well as variants 4, 12-20 and 22, encodes isoform 4.
      Source sequence(s)
      AC242426
      UniProtKB/TrEMBL
      B4DLS6
      Conserved Domains (2) summary
      PLN03142
      Location:1 → 418
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      cd03331
      Location:435 → 585
      Macro_Poa1p-like_SNF2; macrodomain, Poa1p-like family, SNF2 subfamily

    19. NM_001348466.2 → NP_001335395.1  chromodomain-helicase-DNA-binding protein 1-like isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (22), as well as variants 4 and 12-21, encodes isoform 4.
      Source sequence(s)
      AC242426
      UniProtKB/TrEMBL
      B4DLS6
      Conserved Domains (2) summary
      PLN03142
      Location:1 → 418
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      cd03331
      Location:435 → 585
      Macro_Poa1p-like_SNF2; macrodomain, Poa1p-like family, SNF2 subfamily

    20. NM_004284.6 → NP_004275.4  chromodomain-helicase-DNA-binding protein 1-like isoform 1

      See identical proteins and their annotated locations for NP_004275.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC242426
      Consensus CDS
      CCDS927.1
      UniProtKB/Swiss-Prot
      A5YM64, B4DDE1, B5MDZ7, Q53EZ3, Q5VXX7, Q6DD94, Q6PK83, Q86WJ1, Q86XH3, Q96HF7, Q96SP3, Q9BVJ1, Q9NVV8
      UniProtKB/TrEMBL
      X5D2E5
      Related
      ENSP00000358262.4, ENST00000369258.8
      Conserved Domains (2) summary
      cd03331
      Location:716 → 866
      Macro_Poa1p_like_SNF2; Macro domain, Poa1p_like family, SNF2 subfamily. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ...
      cl26465
      Location:46 → 699
      SNF2_N; SNF2 family N-terminal domain

    21. NM_024568.4 → NP_078844.2  chromodomain-helicase-DNA-binding protein 1-like isoform 3

      See identical proteins and their annotated locations for NP_078844.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses a different splice site in the 5' coding region which results in translation from a downstream start codon, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1. Variants 3 and 9 both encode the same isoform (3).
      Source sequence(s)
      AC242426
      UniProtKB/TrEMBL
      X5D2E5
      Conserved Domains (2) summary
      cd03331
      Location:603 → 753
      Macro_Poa1p_like_SNF2; Macro domain, Poa1p_like family, SNF2 subfamily. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ...
      cl26465
      Location:2 → 586
      SNF2_N; SNF2 family N-terminal domain

    RNA

    1. NR_046070.3 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay.(NMD).
      Source sequence(s)
      AC242426
      Related
      ENST00000467213.5

    2. NR_145681.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC242426
      Related
      ENST00000652161.1

    3. NR_145682.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC242426
      Related
      ENST00000650721.1

    4. NR_145683.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC242426
      Related
      ENST00000651410.1

    5. NR_145684.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC242426
      Related
      ENST00000650828.1

    6. NR_145685.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC242426

    7. NR_145686.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC242426
      Related
      ENST00000651407.1

    8. NR_145687.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC242426

    9. NR_145688.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC242426

    10. NR_145689.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC242426
      Related
      ENST00000652616.1

    11. NR_145690.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC242426
      Related
      ENST00000652346.1

    12. NR_145691.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC242426

    13. NR_145692.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC242426
      Related
      ENST00000652494.1

    14. NR_145693.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC242426
      Related
      ENST00000488864.5

    15. NR_145694.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC242426
      Related
      ENST00000652486.1

    16. NR_145695.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC242426
      Related
      ENST00000651207.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      147172747..147295762
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047435001.1 → XP_047290957.1  chromodomain-helicase-DNA-binding protein 1-like isoform X1

    2. XM_024451051.2 → XP_024306819.1  chromodomain-helicase-DNA-binding protein 1-like isoform X2

      UniProtKB/TrEMBL
      A0A494C179
      Related
      ENSP00000498899.1, ENST00000652587.1
      Conserved Domains (2) summary
      cd03331
      Location:289 → 439
      Macro_Poa1p_like_SNF2; Macro domain, Poa1p_like family, SNF2 subfamily. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ...
      cl26465
      Location:1 → 272
      SNF2_N; SNF2 family N-terminal domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      147512572..147635662 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339710.1 → XP_054195685.1  chromodomain-helicase-DNA-binding protein 1-like isoform X2

    2. XM_054339709.1 → XP_054195684.1  chromodomain-helicase-DNA-binding protein 1-like isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86WJ1.3 GenPept UniProtKB/Swiss-Prot:Q86WJ1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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