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    ANP32E acidic nuclear phosphoprotein 32 family member E [ Homo sapiens (human) ]

    Gene ID: 81611, updated on 5-May-2024

    Summary

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    Official Symbol
    ANP32Eprovided by HGNC
    Official Full Name
    acidic nuclear phosphoprotein 32 family member Eprovided by HGNC
    Primary source
    HGNC:HGNC:16673
    See related
    Ensembl:ENSG00000143401 MIM:609611; AllianceGenome:HGNC:16673
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LANPL; LANP-L
    Summary
    Enables histone binding activity. Involved in histone exchange. Located in nucleus. Part of Swr1 complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in lymph node (RPKM 31.5), bone marrow (RPKM 21.4) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ANP32E in Genome Data Viewer
    Location:
    1q21.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (150218417..150236112, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (149343213..149361083, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (150190717..150208460, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1670 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1297 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1298 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1671 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1672 Neighboring gene long intergenic non-protein coding RNA 2988 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1673 Neighboring gene Sharpr-MPRA regulatory region 9169 Neighboring gene CRISPRi-validated cis-regulatory element chr1.8432 Neighboring gene RNA, 7SL, cytoplasmic 480, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1674 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1675 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1299 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1676 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:150208844-150209411 Neighboring gene RNA, U2 small nuclear 17, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:150228359-150229053 Neighboring gene small nucleolar RNA, C/D box 13C Neighboring gene carbonic anhydrase 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Subtype-Independent ANP32E Reduction During Breast Cancer Progression in Accordance with Chromatin Relaxation. Ruff GL, et al. BMC Cancer, 2021 Dec 18. PMID 34922480, Free PMC Article
    2. Over-expression of ANP32E is associated with poor prognosis of pancreatic cancer and promotes cell proliferation and migration through regulating β-catenin. Zhang J, et al. BMC Cancer, 2020 Nov 4. PMID 33148205, Free PMC Article
    3. Up-regulated ANP32E promotes the thyroid carcinoma cell proliferation and migration via activating AKT/mTOR/HK2-mediated glycolysis. Huang J, et al. Gene, 2020 Aug 5. PMID 32304784
    4. ANP32E, a Protein Involved in Steroid-Refractoriness in Ulcerative Colitis, Identified by a Systems Biology Approach. Lorén V, et al. J Crohns Colitis, 2019 Mar 26. PMID 30329026
    5. Molecular cloning and characterization of a novel human gene (ANP32E alias LANPL) from human fetal brain. Jiang M, et al. Cytogenet Genome Res, 2002. PMID 12438741

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ANP32e Binds Histone H2A.Z in a Cell Cycle-Dependent Manner and Regulates Its Protein Stability in the Cytoplasm.
      Title: ANP32e Binds Histone H2A.Z in a Cell Cycle-Dependent Manner and Regulates Its Protein Stability in the Cytoplasm.
    2. An Influenza A virus can evolve to use human ANP32E through altering polymerase dimerization.
      Title: An Influenza A virus can evolve to use human ANP32E through altering polymerase dimerization.
    3. ANP32E contributes to gastric cancer progression via NUF2 upregulation.
      Title: ANP32E contributes to gastric cancer progression via NUF2 upregulation.
    4. Subtype-Independent ANP32E Reduction During Breast Cancer Progression in Accordance with Chromatin Relaxation.
      Title: Subtype-Independent ANP32E Reduction During Breast Cancer Progression in Accordance with Chromatin Relaxation.
    5. Hsa-let-7c exerts an anti-tumor function by negatively regulating ANP32E in lung adenocarcinoma.
      Title: Hsa-let-7c exerts an anti-tumor function by negatively regulating ANP32E in lung adenocarcinoma.
    6. Over-expression of ANP32E is associated with poor prognosis of pancreatic cancer and promotes cell proliferation and migration through regulating beta-catenin.
      Title: Over-expression of ANP32E is associated with poor prognosis of pancreatic cancer and promotes cell proliferation and migration through regulating β-catenin.
    7. Findings suggest that ANP32E promotes THCA cell proliferation and migration via potentiating AKT/mTOR/HK2-mediated glycolysis.
      Title: Up-regulated ANP32E promotes the thyroid carcinoma cell proliferation and migration via activating AKT/mTOR/HK2-mediated glycolysis.
    8. A systems biology approach allowed us to identify a comprehensive mechanism of action of steroid-refractoriness, highlighting the key role of steroid-induced transcription and the potential implication of ANP32E in this phenomenon.
      Title: ANP32E, a Protein Involved in Steroid-Refractoriness in Ulcerative Colitis, Identified by a Systems Biology Approach.
    9. ANP32E is an efficient prognostic marker, and it promotes the G1/S transition and induces tumorigenesis of Triple-negative breast cancer cells by transcriptionally inducing E2F1.
      Title: ANP32E induces tumorigenesis of triple-negative breast cancer cells by upregulating E2F1.
    10. Study identified ANP32E as one of the miR-141 targets, and demonstrated its involvement in the regulation of cell proliferation, migration, and invasion of breast cancer cells.
      Title: Downregulation of miRNA-141 in breast cancer cells is associated with cell migration and invasion: involvement of ANP32E targeting.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, acidic leucine-rich nuclear phosphoprotein 32 E (ANP32E), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with ANP32E is decreased by RRE PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human acidic (leucine-rich) nuclear phosphoprotein 32 family, member E (ANP32E) at amino acid residues 235-236 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC5350

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone chaperone activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein folding chaperone EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Swr1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    acidic leucine-rich nuclear phosphoprotein 32 family member E
    Names
    LANP-like protein
    acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
    leucine-rich acidic nuclear protein like

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136478.4 → NP_001129950.1  acidic leucine-rich nuclear phosphoprotein 32 family member E isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC242988
      Consensus CDS
      CCDS44214.1
      UniProtKB/Swiss-Prot
      Q9BTT0
      Related
      ENSP00000393718.2, ENST00000436748.6

    2. NM_001136479.3 → NP_001129951.1  acidic leucine-rich nuclear phosphoprotein 32 family member E isoform 3

      See identical proteins and their annotated locations for NP_001129951.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at a downstream start codon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC242988
      Consensus CDS
      CCDS44215.1
      UniProtKB/Swiss-Prot
      Q9BTT0
      Related
      ENSP00000481415.1, ENST00000616917.4
      Conserved Domains (2) summary
      sd00033
      Location:18 → 41
      LRR_RI; leucine-rich repeat [structural motif]
      pfam14580
      Location:5 → 98
      LRR_9; Leucine-rich repeat

    3. NM_001280559.2 → NP_001267488.1  acidic leucine-rich nuclear phosphoprotein 32 family member E isoform 4

      See identical proteins and their annotated locations for NP_001267488.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has an alternate splice site in the 3' coding region compared to variant 1. The resulting isoform (4) lacks an internal aa compared to isoform 1.
      Source sequence(s)
      AC242988
      UniProtKB/Swiss-Prot
      Q9BTT0
      Conserved Domains (2) summary
      sd00033
      Location:44 → 65
      LRR_RI; leucine-rich repeat [structural motif]
      pfam14580
      Location:34 → 146
      LRR_9; Leucine-rich repeat

    4. NM_001280560.2 → NP_001267489.1  acidic leucine-rich nuclear phosphoprotein 32 family member E isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks two internal exons compared to variant 1. The resulting isoform (5) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC242988
      Consensus CDS
      CCDS60245.1
      UniProtKB/TrEMBL
      B4E0D5, E9PLC4
      Related
      ENSP00000435215.1, ENST00000533654.5
      Conserved Domains (2) summary
      sd00033
      Location:44 → 65
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:65 → 107
      LRR_4; Leucine Rich repeats (2 copies)

    5. NM_030920.5 → NP_112182.1  acidic leucine-rich nuclear phosphoprotein 32 family member E isoform 1

      See identical proteins and their annotated locations for NP_112182.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC242988
      Consensus CDS
      CCDS946.1
      UniProtKB/Swiss-Prot
      B4E0I6, E9PEA6, Q5TB18, Q5TB20, Q8N1S4, Q8WWW9, Q9BTT0
      Related
      ENSP00000463154.1, ENST00000583931.6
      Conserved Domains (2) summary
      sd00033
      Location:44 → 65
      LRR_RI; leucine-rich repeat [structural motif]
      pfam14580
      Location:34 → 146
      LRR_9; Leucine-rich repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      150218417..150236112 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005245514.5 → XP_005245571.1  acidic leucine-rich nuclear phosphoprotein 32 family member E isoform X3

      See identical proteins and their annotated locations for XP_005245571.1

      Conserved Domains (4) summary
      cd00116
      Location:15 → 146
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:44 → 65
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:88 → 130
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:65 → 125
      LRR_8; Leucine rich repeat

    2. XM_017002418.3 → XP_016857907.1  acidic leucine-rich nuclear phosphoprotein 32 family member E isoform X2

    3. XM_005245513.5 → XP_005245570.1  acidic leucine-rich nuclear phosphoprotein 32 family member E isoform X1

      Conserved Domains (3) summary
      cd09293
      Location:53 → 126
      AMN1; Antagonist of mitotic exit network protein 1
      sd00033
      Location:44 → 65
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:65 → 125
      LRR_8; Leucine rich repeat

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      149343213..149361083 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338923.1 → XP_054194898.1  acidic leucine-rich nuclear phosphoprotein 32 family member E isoform X3

    2. XM_054338921.1 → XP_054194896.1  acidic leucine-rich nuclear phosphoprotein 32 family member E isoform X1

    3. XM_054338922.1 → XP_054194897.1  acidic leucine-rich nuclear phosphoprotein 32 family member E isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BTT0.1 GenPept UniProtKB/Swiss-Prot:Q9BTT0

    Gene LinkOut

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